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Amphotericin B trihydrate (Synonyms: 两性霉素B三水合物)
Amphotericin B trihydrate 是一种多烯抗生素,最初是从 Streptomyces nodosus 发酵菌种分离出来,具有抗利什曼虫的活性。
Amphotericin B trihydrate Chemical Structure
CAS No. : 1202017-46-6
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Amphotericin B trihydrate 的其他形式现货产品:
生物活性 |
Amphotericin B trihydrate, a polyene antibiotic, is first isolated from fermenter cultures of Streptomyces nodosus. Amphotericin B trihydrate also possesses antileishmanial activity[1][2]. |
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体外研究 (In Vitro) |
Amphotericin B interacts with cholesterol, the major sterol of mammal membranes, thus limiting the usefulness of Amphotericin B due to its relatively high toxicity. Amphotericin B is dispersed as a pre-micellar or as a highly aggregated state in the subphase[4]. Amphotericin B only kills unicellular Leishmania promastigotes (LPs) when aqueous pores permeable to small cations and anions are formed. Amphotericin B (0.1 mM) induces a polarization potential, indicating K+ leakage in KCl-loaded liposomes suspended in an iso-osmotic sucrose solution. Amphotericin B (0.05 mM) exhibits a nearly total collapse of the negative membrane potential, indicating Na+ entry into the cells[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Amphotericin B results in prolonging the incubation time and decreasing PrPSc accumulation in the hamster scrapie model. Amphotericin B markedly reduces PrPSc levels in mice with transmissible subacute spongiform encephalopathies (TSSE)[4]. Amphotericin B exerts a direct effect on Plasmodium falciparum and influences eryptosis of infected erythrocytes, parasitemia and hostsurvival in murine malaria. Amphotericin B tends to delay the increase of parasitemia and significantly delays host death plasmodium berghei-infected mice[5]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
978.12 |
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Formula |
C47H79NO20 |
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CAS 号 |
1202017-46-6 |
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中文名称 |
两性霉素B三水合物 |
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结构分类 |
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初始来源 |
actinomycete Streptomyces nodosus |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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纯度 & 产品资料 |
Data Sheet (537 KB) 产品使用指南 (1538 KB)
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参考文献 |
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