Obtusifoliol

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Obtusifoliol  纯度: 99.86%

Obtusifoliol 是一种特异的 CYP51 抑制剂,Obtusifoliol 对布鲁氏锥虫 (TB) 和人 CYP51 的亲和力的 Kd 值分别为 1.2 µM 和 1.4 µM。

Obtusifoliol

Obtusifoliol Chemical Structure

CAS No. : 16910-32-0

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Obtusifoliol 相关产品

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生物活性

Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with Kd values of 1.2 µM and 1.4 µM for Trypanosoma brucei (TB) and human CYP51, respectively[1].

IC50 & Target

CYP51

 

Trypanosoma

 

体外研究
(In Vitro)

Obtusifoliol (0.1-100 µM; 48 hours) inhibit MCF-7 and MDA-MB231 breast cancer cells proliferation via arresting cell cycle progression and induction of apoptosis[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Obtusifoliol 相关抗体:

Cell Viability Assay[2]

Cell Line: MCF-7; MDA-MB231 breast cancer cells
Concentration: 0.1, 1, 10, 40, 80, and 100 µM
Incubation Time: 48 hours
Result: Inhibited MCF-7 and MDA-MB231 breast cancer cells proliferation.

分子量

426.72

Formula

C30H50O

CAS 号

16910-32-0

性状

固体

颜色

White to off-white

结构分类
  • Others
初始来源
  • 植物
  • 禾本科
  • 高粱
  • 内源性代谢物
  • 人肠道微生物代谢物
  • 微生物
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 99.86%

Data Sheet (527 KB) SDS (251 KB)

COA (194 KB) HNMR (119 KB) RP-HPLC (281 KB)

产品使用指南 (1538 KB)

参考文献
  • [1]. Lepesheva GI, et al. CYP51 from Trypanosoma brucei is obtusifoliol-specific.Biochemistry. 2004 Aug 24;43(33):10789-99.  [Content Brief]

    [2]. Aghaei M, et al Obtusifoliol related steroids from Euphorbia sogdiana with cell growth inhibitory activity and apoptotic effects on breast cancer cells (MCF-7 and MDA-MB231). Steroids. 2016 Nov;115:90-97. doi: 10.1016/j.steroids.2016.07.008. Epub 2016 Jul 26.  [Content Brief]

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