月度归档：2022年08月

Givinostat impurity 1-d10 hydrochloride

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Givinostat impurity 1-d10 hydrochloride 

Givinostat impurity 1-d10 (hydrochloride) 是 Givinostat impurity 1 氘代物。

Givinostat impurity 1-d10 hydrochloride

Givinostat impurity 1-d10 hydrochloride Chemical Structure

规格 是否有货
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生物活性

Givinostat impurity 1-d10 (hydrochloride) 是 Givinostat impurity 1氘代物[1]。

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

303.85

Formula

C16H10D10ClNO2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

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Ceftiofur-d3 sodium

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Ceftiofur-d3 sodium 

Ceftiofur-d3 (sodium) 是 Ceftiofur (sodium) 氘代物。Ceftiofurna钠是第三代头孢菌素类抗生素，已批准用于兽医用途。

Ceftiofur-d3 sodium

Ceftiofur-d3 sodium Chemical Structure

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生物活性

Ceftiofur-d3 (sodium) is deuterium labeled Ceftiofur (sodium).

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

548.56

Formula

C19H13D3N5NaO7S3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Dutil L, et al. Ceftiofur resistance in Salmonella enterica serovar Heidelberg from chicken meat and humans, Canada. Emerg Infect Dis. 2010 Jan;16(1):48-54.

    [3]. Yancey RJ Jr, et al. Ceftiofur sodium, a broad-spectrum cephalosporin: evaluation in vitro and in vivo in mice. Am J Vet Res. 1987 Jul;48(7):1050-3.

    [4]. Salmon SA, et al. In vitro activity of ceftiofur and its primary metabolite, desfuroylceftiofur, against organisms of veterinary importance. J Vet Diagn Invest. 1996 Jul;8(3):332-6.

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Sphinganine 1-phosphate-d7

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Sphinganine 1-phosphate-d7 

Sphinganine 1-phosphate-d7 是 Sphinganine 1-phosphate 的氘代物。Sphinganine 1-phosphate 是一种极性鞘脂代谢物，可调节细胞迁移、细胞分化等众多生理过程。

Sphinganine 1-phosphate-d7

Sphinganine 1-phosphate-d7 Chemical Structure

CAS No. : 2315262-23-6

规格 是否有货
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生物活性

Sphinganine 1-phosphate-d7 is deuterium labeled Sphinganine 1-phosphate. Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiologic

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

388.53

Formula

C18H33D7NO5P
CAS 号

2315262-23-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Montserrat Serra, et al. Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Adv Enzyme Regul. 2010;50(1):349-62.

    [2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

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Raloxifene 4′-glucuronide-d4 lithium

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Raloxifene 4′-glucuronide-d4 lithium 

Raloxifene 4′-glucuronide-d4 (lithium) 是 Raloxifene 4′-glucuronide 氘代物。Raloxifene 4′-glucuronide 是 Raloxifene 的主要代谢产物。Raloxifene 4′-glucuronide 的形成主要由 UGT1A10 和 UGT1A8 介导，以 IC50 为 370 μM 与 estrogen receptor 结合。Raloxifene 是选择性雌激素受体调节剂。 Raloxifene 在纳摩尔浓度激活 TGFβ3 启动子为完全激动剂，并抑制含雌激素反应元件的卵黄蛋白原启动子的表达。

Raloxifene 4'-glucuronide-d4 lithium

Raloxifene 4′-glucuronide-d4 lithium Chemical Structure

规格 是否有货
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生物活性

Raloxifene 4′-glucuronide-d4 (lithium) is deuterium labeled Raloxifene 4′-glucuronide. Raloxifene 4′-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4′-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4′-glucuronide binds to estrogen receptor with an IC50 of 370 μM. [1][2]. Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression[3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

659.67

Formula

C34H30D4LiNO10S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Izgelov D, et al. The Effect of Piperine Pro-Nano Lipospheres on Direct Intestinal Phase II Metabolism: The Raloxifene Paradigm of Enhanced Oral Bioavailability. Mol Pharm. 2018 Apr 2;15(4):1548-1555.

    [3]. Kemp DC, et al. Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to presystemic clearance. Drug Metab Dispos. 2002 Jun;30(6):694-700.

    [4]. Yang NN, et al. Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: a potential mechanism for estrogen- or raloxifene-mediated bone maintenance. Endocrinology. 1996 May;137(5):2075-84.

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D-2-Aminohexanoic acid-d9

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
D-2-Aminohexanoic acid-d9 

D-2-Aminohexanoic acid-d9 是 D-2-Aminohexanoic acid 氘代物。

D-2-Aminohexanoic acid-d9

D-2-Aminohexanoic acid-d9 Chemical Structure

CAS No. : 2185812-01-3

规格 是否有货
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生物活性

D-2-Aminohexanoic acid-d9 is the deuterium labeled D-2-Aminohexanoic acid.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

140.23

Formula

C6H4D9NO2
CAS 号

2185812-01-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Ganglioside GM3-d5 Bovine Milk ammonium salt

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Ganglioside GM3-d5 Bovine Milk ammonium salt 

Ganglioside GM3-d5 (Bovine Milk ammonium salt) 是 Ganglioside GM3 (Bovine Milk ammonium salt) 的氘代物。

Ganglioside GM3-d5 Bovine Milk ammonium salt

Ganglioside GM3-d5 Bovine Milk ammonium salt Chemical Structure

CAS No. : 2260669-91-6

规格 是否有货
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250 mg   询价  
500 mg   询价  

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生物活性

Ganglioside GM3-d5 (Bovine Milk ammonium salt) is deuterium labeled Ganglioside GM3 (Bovine Milk ammonium salt).

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1203.55

Formula

C59H106D5N3O21
CAS 号

2260669-91-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Dihydrolanosterol-d7

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Dihydrolanosterol-d7 

Dihydrolanosterol-d7 是 Dihydrolanosterol 的氘代物。Dihydrolanosterol 是 CYP51 的底物之一，抑制胆固醇合成。

Dihydrolanosterol-d7

Dihydrolanosterol-d7 Chemical Structure

CAS No. : 2260669-12-1

规格 是否有货
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生物活性

Dihydrolanosterol-d7 is deuterium labeled Dihydrolanosterol. Dihydrolanosterol is a subtrate of CYP51 and a cholesterol biosynthesis inhibitor[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

435.78

Formula

C30H45D7O
CAS 号

2260669-12-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lepesheva GI, Waterman MR. Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms. Biochim Biophys Acta. 2007;1770(3):467-477.

    [2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cyclobenzaprine impurity 2-d3 hydrochloride

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Cyclobenzaprine impurity 2-d3 hydrochloride 

Cyclobenzaprine impurity 2-d3 (hydrochloride) 是 Cyclobenzaprine impurity 2 氘代物。

Cyclobenzaprine impurity 2-d3 hydrochloride

Cyclobenzaprine impurity 2-d3 hydrochloride Chemical Structure

规格 是否有货
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生物活性

Cyclobenzaprine impurity 2-d3 (hydrochloride) 是 Cyclobenzaprine impurity 2氘代物[1]。

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

531.14

Formula

C37H31D3ClN
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Lafutidine-d10

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Lafutidine-d10 

Lafutidine-d10 是 Lafutidine 氘代物。Lafutidine (FRG-8813) 是一种组胺受体 H2RA 拮抗剂，具有胃粘膜保护作用。Lafutidine 可用于胃食管反流疾病的研究。

Lafutidine-d10

Lafutidine-d10 Chemical Structure

CAS No. : 1795136-26-3

规格 是否有货
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生物活性

Lafutidine-d10 is deuterium labeled Lafutidine. Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H2RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

441.61

Formula

C22H19D10N3O4S
CAS 号

1795136-26-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Motoko Nakano, et al. Possible involvement of host defense mechanism in the suppression of rat acute reflux esophagitis by the particular histamine H2 receptor antagonist lafutidine. Pharmacology. 2012;90(3-4):205-11.

    [3]. Tetsuhiro Sugiyama, et al. Lafutidine facilitates calcitonin gene-related peptide (CGRP) nerve-mediated vasodilation via vanilloid-1 receptors in rat mesenteric resistance arteries. J Pharmacol Sci. 2008 Mar;106(3):505-11.

    [4]. Mitsuaki Okayama, et al. Protective effect of lafutidine, a novel histamine H2-receptor antagonist, on dextran sulfate sodium-induced colonic inflammation through capsaicin-sensitive afferent neurons in rats. Dig Dis Sci. 2004 Oct;49(10):1696-704.

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Methionine-d3(Synonyms: MRX-1024-d3; D-Methionine-d3)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Methionine-d3 (Synonyms: MRX-1024-d3; D-Methionine-d3)

Methionine-d3 是 Methionine 氘代物。Methionine (MRX-1024; D-Methionine) 是一种有效的化学保护剂，它还可以通过激活 GABAA 受体来抑制神经元活性。

Methionine-d3(Synonyms: MRX-1024-d3; D-Methionine-d3)

Methionine-d3 Chemical Structure

CAS No. : 284665-18-5

规格 是否有货
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生物活性

Methionine-d3 is the deuterium labeled Methionine. Methionine (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

152.23

Formula

C5H8D3NO2S
CAS 号

284665-18-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Wu C, et al. Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition. J Neural Transm (Vienna). 2014 Jul;121(7):683-93.

    [3]. Sooriyaarachchi M, et al. Chemoprotection by D-methionine against cisplatin-induced side-effects: insight from in vitrostudies using human plasma. Metallomics. 2014 Mar;6(3):532-41.

    [4]. Hinduja S, et al. D-methionine protects against cisplatin-induced neurotoxicity in the hippocampus of the adult rat. Neurotox Res. 2015 Apr;27(3):199-204.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务