标签归档：pectin

Pectin

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Pectin 

Pectin 是一种杂多糖，可从高等植物的细胞壁获得。Pectin 能够制成纳米颗粒，作为活性分子的运载载体。Pectin 也是一种吸附剂，一种广谱抗菌剂，可以结合肠道粘膜中的细菌毒素和其他刺激物，缓解受刺激的黏膜。

Pectin

Pectin Chemical Structure

CAS No. : 9000-69-5

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Pectin 相关产品

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•同靶点蛋白产品:

生物活性

Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of agents. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Pectin (5 mg/mL; 24, 48, and 72 h) shows low cytotoxicity on HepG2 cells, and can be made into nanoparticles (PPN), encapsulating Paclitaxel (HY-B0015), decreases the Paclitaxel cytotoxicity (%) from 55.6% to 21.7% at 72 h[1].
Pectin (3, 6 mg/mL; 48 h) inhibits Staphylococcus aureus ATCC 25923 growth, with a minimum inhibitory concentration (MIC) of 40 mg/mL[2].
Pectin inhibits Gram-negative Helicobacter pylori, a common human pathogen, shows highest antibacterial activity at pH 5.0, with a minimum inhibitory concentration (MIC) of 0.162 mg/mL and minimum bactericidal concentration (MBC) of 0.325 mg/mL[2].
Pectin displays lower antibacterial activity against E. coli with MICs of 25 mg/mL and 50 mg/mL and MBC values ranging between 25-50 mg/mL[2].
Pectin exhibits the antibacterial activity via its undissociated acid form[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Pectin 相关抗体:
体内研究
(In Vivo)

Pectin serves as the nanoparticles encapsulating Paclitaxel (HY-B0015), (20 mg/kg; i.v.; single dose) significantly delays plasma clearance with detection of Paclitaxel possible up to 48 h in Balb/c mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

CAS 号

9000-69-5
结构分类
  • Saccharides
  • Polysaccharides
  • Others
初始来源
  • 植物
  • 蔷薇科
  • 苹果
  • 内源性代谢物
  • 人肠道微生物代谢物
  • 微生物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (533 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Verma AK, et al. Pharmacokinetics and biodistribution of negatively charged pectin nanoparticles encapsulating paclitaxel. Cancer Nanotechnol. 2013;4(4-5):99-102.   [Content Brief]

    [2]. Ciriminna R, et al. Pectin: A Long-Neglected Broad-Spectrum Antibacterial. ChemMedChem. 2020 Dec 3;15(23):2228-2235.   [Content Brief]

    [3]. Wikiera A, et al. Prozdrowotne właściwości pektyn [Health-promoting properties of pectin]. Postepy Hig Med Dosw (Online). 2014 Jan 2;68:590-6. Polish.  [Content Brief]

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