Enterolactone

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Enterolactone 

Enterolactone 是一种生物活性酚类代谢物，被称为哺乳动物木酚素，来源于膳食木酚素。Enterolactone 具有雌激素特性和抗乳腺癌活性。Enterolactone 是人乳腺癌细胞系的放射增敏剂，通过受损的 DNA修复和增加的细胞凋亡 (apoptosis)。

Enterolactone

Enterolactone Chemical Structure

CAS No. : 78473-71-9

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Enterolactone 相关产品

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生物活性

Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis[2].

体外研究
(In Vitro)

Enterolactone (25-75 μM; 48 hours) arrests the growth of MDA-MB-231 breast cancer cells in the ‘S’ phase[1]
Enterolactone (25-75 μM; 15 hours) triggers apoptosis in MDA-MB-231 breast cancer cells via caspase-3 activation[1].
Enterolactone inhibits TGF-β-induced migration of MDA-MB-231 breast cancer cells. Enterolactone inhibits TGF-β-induced invasion of MDA-MB-231 breast cancer cells through ECM. Enterolactone inhibits the TGF-β-induced EMT program in MDA-MB-231 breast cancer cells. Enterolactone reduces the formation of actin stress fibers by inhibiting the expression of CD44 and MAPK-p38. Enterolactone inhibits the ERK/NF-κB/Snail signaling pathway to revert TGF-β-induced EMT in MDA-MB-231 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Enterolactone 相关抗体:

Cell Viability Assay[1]

Cell Line: MDA-MB-231 cells
Concentration: 25, 50, 75 μM
Incubation Time: 48 hours
Result: There was a non-significant increase (~24%) in the S phase population following treatment with 25 μM EL, whereas there were significant increases (~34% and ~39%) following treatment with 50 and 75 μM EL, respectively.

分子量

298.33

Formula

C18H18O4
CAS 号

78473-71-9
性状

液体

颜色

Colorless to light yellow

结构分类
  • Phenylpropanoids
  • Lignans
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (540 KB) SDS (393 KB)

COA (273 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Bigdeli B, et al. Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis. Toxicol Appl Pharmacol. 2016;313:180-194.  [Content Brief]

    [2]. Mali AV, et al. Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial-mesenchymal transition. Cancer Biol Med. 2018;15(2):137-156.  [Content Brief]

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