Eicosapentaenoic Acid sodium (Synonyms: 二十碳五烯酸钠盐; EPA sodium; Timnodonic acid sodium)

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Eicosapentaenoic Acid sodium  (Synonyms: 二十碳五烯酸钠盐; EPA sodium; Timnodonic acid sodium)

Eicosapentaenoic Acid (EPA) sodium 是一种具有口服活性的 ω-3 长链多不饱和脂肪酸 (ω-3 LC-PUFAs)。Eicosapentaenoic Acid sodium 具有促进肿瘤抑制基因 CCAAT/增强子结合蛋白δ (C/EBPδ) 重新表达的 DNA 去甲基化作用。Eicosapentaenoic Acid sodium 通过 H-RAS 内含子 1 CpG 岛去甲基化激活 U937 白血病细胞中的 RAS/ERK/C/EBPβ 途径。Eicosapentaenoic Acid sodium 能促进血管平滑肌细胞的松弛和血管舒张。

Eicosapentaenoic Acid sodium (Synonyms: 二十碳五烯酸钠盐; EPA sodium; Timnodonic acid sodium)

Eicosapentaenoic Acid sodium Chemical Structure

CAS No. : 73167-03-0

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Eicosapentaenoic Acid sodium 的其他形式现货产品:

Eicosapentaenoic Acid

Eicosapentaenoic Acid sodium 相关产品

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生物活性

Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].

IC50 & Target[1][2][3]

Human Endogenous Metabolite

 

体外研究
(In Vitro)

C/EBPβ phosphorylated form is evident in Eicosapentaenoic Acid (EPA; 100 µM; 24 h) sodium treated cells, whereas it was barely detectable in control, and OA or LA treated U937[1].
Eicosapentaenoic Acid (100 µM; 1, 3, 24 h) sodium causes a significant increase of H-Ras and N-Ras mRNA levels conditioning for 1 and 3 hours. K-Ras mRNA levels were not affected by Eicosapentaenoic Acid sodium[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Eicosapentaenoic Acid sodium 相关抗体:
Clinical Trial

分子量

324.43

Formula

C20H29NaO2
CAS 号

73167-03-0
中文名称

二十碳五烯酸钠盐
结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (531 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Veronica Ceccarelli, et al.  Eicosapentaenoic acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. PLoS One. 2014 Jan 13;9(1):e85025.  [Content Brief]

    [2]. Miaozhen Pan, et al. Dietary ω-3 polyunsaturated fatty acids are protective for myopia. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2104689118.  [Content Brief]

    [3]. Shun-he Wang, et al. Endogenous omega-3 long-chain fatty acid biosynthesis from alpha-linolenic acid is affected by substrate levels, gene expression, and product inhibition. RSC Adv., 2017, 7, 40946-40951.

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