Malvidin-3-O-arabinoside chloride

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
Malvidin-3-O-arabinoside chloride 

Malvidin-3-O-arabinoside chloride 通过刺激 Ampk 介导的自噬 (autophagy),改善氨基甲酸乙酯诱导的氧化损伤。

Malvidin-3-O-arabinoside chloride

Malvidin-3-O-arabinoside chloride Chemical Structure

CAS No. : 28500-04-1

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Malvidin-3-O-arabinoside chloride 相关产品

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生物活性

Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy[1].

体外研究
(In Vitro)

Malvidin-3-O-arabinoside chloride (M3A chloride, 50-400 μM) pretreatment remarkably upregulates LAMP-1 expression, which indicates elevated lysosomal mass. M3A also successfully restores lysosomal acidity and subsequently strengthenes lysosomal functions. M3A stimulates phosphorylation of AMP-activated protein kinase (AMPK), a master regulator of autophagy[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Malvidin-3-O-arabinoside chloride 相关抗体:

Cell Autophagy Assay[1]

Cell Line: Caco-2 cell line.
Concentration: 50, 100, 200 and 400 μM.
Incubation Time: 24 h (then treated with or without 10 μM chloroquine (CQ) for another 1 h).
Result: Notably inhibited excess ROS generation.
200 μM and 400 μM M3A pretreatment significantly enhanced 14% and 16% of GSH level.
Enhanced autophagy flux.
Significantly up-regulate the LC3-II/LC3-I ratio.

分子量

498.86

Formula

C22H23ClO11

CAS 号

28500-04-1

结构分类
  • Flavonoids
  • Anthocyans
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 杜鹃花科
  • 黑果越桔
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
Data Sheet (533 KB) 产品使用指南 (1538 KB)

参考文献
  • [1]. Yuting Li, et al. Malvidin-3-O-arabinoside ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy. Food Funct. 2020 Dec 1;11(12):10317-10328.  [Content Brief]

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