Oxytetracycline calcium (Synonyms: 土霉素钙)

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Oxytetracycline calcium  (Synonyms: 土霉素钙)

Oxytetracycline calcium 是一种属于四环素类的抗生素。Oxytetracycline calcium强力抑制革兰氏阴性和革兰氏阳性细菌。Oxytetracycline calcium 是一种蛋白质合成抑制剂,可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合。Oxytetracycline calcium 还具有抗 HSV-1 的活性。

Oxytetracycline calcium                                          (Synonyms: 土霉素钙)

Oxytetracycline calcium Chemical Structure

CAS No. : 7179-50-2

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Oxytetracycline calcium 的其他形式现货产品:

Oxytetracycline Oxytetracycline hydrochloride

Oxytetracycline calcium 相关产品

同靶点产品:

同靶点蛋白产品:

生物活性

Oxytetracycline calcium is an antibiotic belonging to the tetracycline class. Oxytetracycline calcium potently inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline calcium is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline calcium also possesses anti-HSV-1 activity[1][2][3].

IC50 & Target

HSV-1

 

Tetracycline

 

Human Endogenous Metabolite

 

Microbial Metabolite

 

体外研究
(In Vitro)

Oxytetracycline calcium is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline calcium is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Oxytetracycline calcium 相关抗体:

体内研究
(In Vivo)

The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) calcium for 10 days are species specific. Oxytetracycline calcium increases the relative liver weight in Morone chrysops x M. saxatilis, the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter[1].
For Oxytetracycline calcium, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline calcium is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

500.51

Formula

C22H24CaN2O9

CAS 号

7179-50-2

中文名称

土霉素钙

结构分类
  • Quinones
  • Anthraquinones
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
Data Sheet (540 KB) 产品使用指南 (1538 KB)

参考文献
  • [1]. Elia, A.C., et al., Transferability of oxytetracycline (OTC) from feed to carp muscle and evaluation of the antibiotic effects on antioxidant systems in liver and kidney. Fish Physiol Biochem, 2014.  [Content Brief]

    [2]. Pickens LB, et al. Oxytetracycline biosynthesis. J Biol Chem. 2010 Sep 3;285(36):27509-15.  [Content Brief]

    [3]. Oguz Guvenmez, et al. A New Treatment Method for Herpes Simplex Virus Type 1-related Skin Lesions. Scientific & Academic. 2019; 8(1): 6-8.

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