标签归档：folic

Folic acid sodium (Synonyms: Vitamin B9 sodium; Vitamin M sodium)

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Folic acid sodium  (Synonyms: Vitamin B9 sodium; Vitamin M sodium)

Folic acid (Vitamin B9) sodium 是一种来自维生素 B 群的口服活性必需营养素。Folic acid sodium 具有抗抑郁样作用。Folic acid sodium 可降低新生儿神经管缺陷的风险。Folic acid sodium 可用于研究因叶酸缺乏引起的巨幼红细胞性贫血和大红细胞性贫血。

Folic acid sodium (Synonyms: Vitamin B9 sodium; Vitamin M sodium)

Folic acid sodium Chemical Structure

CAS No. : 6484-89-5

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Folic acid sodium 的其他形式现货产品:

Folic acid Folic acid disodium

Folic acid sodium 相关产品

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生物活性

Folic acid (Vitamin B9) sodium is a orally active essential nutrient from the B complex group of vitamins. Folic acid sodium shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid sodium can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency[1][2][3][4].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Folic acid sodium plays a critical role in the prevention of chromosome breakage and hypomethylation of DNA[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Folic acid sodium 相关抗体:
体内研究
(In Vivo)

Folic acid sodium (10, 50, 100 mg/kg; p.o.) shows an antidepressant-like effect in this behavioral mouse model[2].
Folic acid sodium (1, 10 nmol/site) shows no psychostimulant effect in mice habituated to the novel environment[2].
Folic acid sodium (1, 5 mg/kg; p.o.) prevents epigenetic modification of hepatic gene expression in the offspring in rats[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 30-40 g swiss mice[2]
Dosage: 10, 50, 100 mg/kg
Administration: Oral administration
Result: Decreased the immobility time in the forced swimming test (FST) (F324=11.21) and produced a significant effect in the immobility time in the tail suspension test (TST) (F3,20=5.71).
Animal Model: 30-40 g swiss mice[2]
Dosage: 1-10 nmol/site
Administration: Intracerebroventrical injection
Result: Decreased the immobility time of mice in the FST (F3,22=12.31) and TST (F3,22=5.50).
Animal Model: Virgin female Wistar rats[3]
Dosage: 1, 5 mg/kg (180 g/kg protein with 1 mg/kg folic acid or 90 g/kg casein with 1, 5 mg/kg folic acid)
Administration: Oral administration
Result: Prevented epigenetic modification of hepatic gene expression in the offspring.

Clinical Trial

分子量

464.39

Formula

C19H19N7NaO6
CAS 号

6484-89-5
中文名称

叶酸钠
结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro: 

H2O 中的溶解度 : 100 mg/mL (215.34 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1534 mL 10.7668 mL 21.5336 mL
5 mM 0.4307 mL 2.1534 mL 4.3067 mL
10 mM 0.2153 mL 1.0767 mL 2.1534 mL

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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浓度

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分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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给药剂量

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动物数量

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工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
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纯度 & 产品资料
Data Sheet (596 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Butterworth CE Jr, et al. Folic acid safety and toxicity: a brief review. Am J Clin Nutr. 1989 Aug;50(2):353-8.  [Content Brief]

    [2]. Brocardo PS, et al. Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems. Neuropharmacology. 2008 Feb;54(2):464-73.  [Content Brief]

    [3]. Lillycrop KA, et al. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005 Jun;135(6):1382-6.  [Content Brief]

    [4]. Pietrzik K, et al. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010 Aug;49(8):535-48.  [Content Brief]

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