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Uridine 5′-diphosphate sodium salt (Synonyms: 尿苷-5′-二磷酸钠盐)

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Uridine 5′-diphosphate sodium salt  (Synonyms: 尿苷-5′-二磷酸钠盐)

Uridine 5′-diphosphate sodium salt 是一种有效的选择性 P2Y6 受体天然激动剂 (EC50=300 nM; pEC50=6.52)，也是一种有效的 P2Y14 拮抗剂 (pEC50=7.28)。Uridine 5′-diphosphate sodium salt 是一种内源性代谢产物 (endogenous metabolite)，可催化多种底物的葡糖醛酸糖化反应，可用于核酸生物合成 (RNA biosynthesis)。

Uridine 5

Uridine 5′-diphosphate sodium salt Chemical Structure

CAS No. : 21931-53-3

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Uridine 5′-diphosphate sodium salt 的其他形式现货产品:

Uridine-5′-diphosphate disodium salt

Uridine 5′-diphosphate sodium salt 相关产品

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生物活性

Uridine 5′-diphosphate sodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine 5′-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Uridine 5′-diphosphate sodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression[2].
Uridine 5′-diphosphate sodium salt (100 μM; 3 hours) induces chemokine expression in microglia[2].
Uridine 5′-diphosphate sodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2].
UDP (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2].
Uridine 5′-diphosphate sodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Uridine 5′-diphosphate sodium salt 相关抗体:

RT-PCR[2]

Cell Line: Primary microglia
Concentration: 100 μM
Incubation Time: For 15 min
Result: Significantly induced microglial CCL2 and CCL3 mRNA expression.

Formula

C9H14N2O12P2.xNa
CAS 号

21931-53-3
中文名称

尿苷-5′-二磷酸钠盐
结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (536 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89.  [Content Brief]

    [2]. Kim B, et al. Uridine 5′-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186(6):3701-9.  [Content Brief]

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