ε-​Viniferin (Synonyms: epsilon-Viniferin)

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ε-​Viniferin  (Synonyms: epsilon-Viniferin) 纯度: ≥98.0%

ε-Viniferin (epsilon-Viniferin) 可以从Vitis vinifera 提取得到,是一种 Resveratrol 的二聚体,可有效抑制 CYP 家族,Ki 值在0.5-20 μM 之间。ε-Viniferin 具有强大的抗氧化、抗炎、抗糖尿病和抗神经退行性疾病活性。

ε-​Viniferin                                          (Synonyms: epsilon-Viniferin)

ε-​Viniferin Chemical Structure

CAS No. : 62218-08-0

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ε-​Viniferin 相关产品

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生物活性

ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol and can be isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with Ki values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity[1][2][3].

IC50 & Target

CYP2B6

3 μM (Ki, (BROD))

CYP1A2

5 μM (Ki, (EROD))

CYP3A4

10 μM (Ki, (TST))

CYP4A

15 μM (IC50, (LwOH))

CYP2E1

25 μM (IC50, (CHZ))

CYP2A6

60 μM (Ki, (COH))

体外研究
(In Vitro)

ε-​Viniferin (1-15 μM,24-72 小时) 抑制 HOS、U2OS 和 A549 细胞的增殖[3]
ε-​Viniferin (20 μM,24 小时) 在 HOS、U2OS、A549 细胞中诱导 DNA 片段化和核浓缩[3]
ε-​Viniferin (10 μM,1 小时) 抑制 TGF-β1 诱导的 A549 细胞 EMT、侵袭和迁移,并逆转 TGF-β1 诱导的 ROS、MMP2、波形蛋白、Zeb1、Snail、p-SMAD2、p-SMAD3 和 ABCG2 表达 [4]
ε-​Viniferin (10 μM,3 分钟) 抑制 fMLP (0.1 μM) 诱导的人中性粒细胞中超氧阴离子的产生,以及 fMLP 诱导的 ERK、Akt、Src 磷酸化或细胞内钙动员[5]
ε-​Viniferin (50 nM-10 μM,48 小时) 通过 SIRT3/FOXO3 途径保护细胞免受鱼藤酮 (HY-B1756) 诱导的 SH-SY5Y 细胞神经毒性[6]
ε-​Viniferin (1 μM,24 小时) 抑制鱼藤酮 Rotenone (HY-B1756) 诱导的 SH-SY5Y 细胞中线粒体去极化和氧化应激[6]

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

ε-​Viniferin 相关抗体:

Western Blot Analysis[4]

Cell Line: A549 cells
Concentration: 10 μM
Incubation Time: 1 h
Result: Inhibited TGF-β1-induced MMP2, vimentin, Zeb1, p-SMAD2, p-SMAD3, and ABCG2 expression.

体内研究
(In Vivo)

ε-​Viniferin (5 mg/kg,腹腔注射,每周 5 天,持续 4 周) 抑制 A549 细胞异种移植裸鼠模型中的肿瘤生长 (无肝肾损伤),并抑制 A549 细胞肺转移小鼠模型中的肿瘤转移[3][4]
ε-​Viniferin (饮食中 0.2%,4 周) 可预防小鼠饮食诱发的肥胖[7]

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A549 cell xenograft nude mice model[3]
Dosage: 5 mg/kg
Administration: i.p., 5 days per week for 4 weeks
Result: Inhibited tumor weight and volume.
Induced apoptosis in tumor sections.
Decreased serum ALT, AST, bilirubin, and creatinine levels.

分子量

454.47

Formula

C28H22O6

CAS 号

62218-08-0

性状

固体

颜色

Off-white to gray

结构分类
  • Phenols
  • Polyphenols
  • Stilbenes
初始来源
  • 植物
  • 葡萄科
  • 葡萄
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

纯度: ≥98.0%

Data Sheet (546 KB) SDS (252 KB)

COA (273 KB)

产品使用指南 (1538 KB)

参考文献
  • [1]. Piver B, et al. Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. Life Sci. 2003 Jul 18;73(9):1199-213.  [Content Brief]

    [2]. XAVIER VITRAC, et al. Determination of Stilbenes (δ-viniferin, trans-astringin, trans-piceid, cis- and trans-resveratrol, E-viniferin) in Brazilian Wines. J. Agric. Food Chem. 2005, 53, 5664−5669.

    [3]. Huang C, et al. ε-Viniferin and α-viniferin alone or in combination induced apoptosis and necrosis in osteosarcoma and non-small cell lung cancer cells. Food Chem Toxicol. 2021 Dec;158:112617.  [Content Brief]

    [4]. Chiou WC, et al. α-Viniferin and ε-Viniferin Inhibited TGF-β1-Induced Epithelial-Mesenchymal Transition, Migration and Invasion in Lung Cancer Cells through Downregulation of Vimentin Expression. Nutrients. 2022 May 30;14(11):2294.  [Content Brief]

    [5]. Liao HR, et al. The anti-inflammatory effect of ε-viniferin by specifically targeting formyl peptide receptor 1 on human neutrophils. Chem Biol Interact. 2021 Aug 25;345:109490.  [Content Brief]

    [6]. Zhang S, et al. Neuroprotective mechanisms of ε-viniferin in a rotenone-induced cell model of Parkinson’s disease: significance of SIRT3-mediated FOXO3 deacetylation. Neural Regen Res. 2020 Nov;15(11):2143-2153.  [Content Brief]

    [7]. Ohara K, et al. ε-Viniferin, a resveratrol dimer, prevents diet-induced obesity in mice. Biochem Biophys Res Commun. 2015 Dec 25;468(4):877-82.  [Content Brief]

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