Phoyunnanin E

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Phoyunnanin E 

Phoyunnanin E，分离自铁皮石斛，具有抗迁移活性。Phoyunnanin E可用于癌症研究。

Phoyunnanin E

Phoyunnanin E Chemical Structure

CAS No. : 886747-60-0

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生物活性

Phoyunnanin E, isolated from Dendrobium venustum, possesses anti-migration activity. Phoyunnanin E can be used for the research of cancer[1].

体外研究
(In Vitro)

Phoyunnanin E (0~10 μM; 48 hours; H460 cells) decreases cell migration through integrin downregulation[1].
Phoyunnanin E (0~100 μM; 24 and 48 hours; H460 cells) shows that the proliferation rate of treated cells have significantly decreased in a dose-dependent manner at the concentration of 10 μM at 48 hours[1].
Phoyunnanin E (0~100 μM; 24 hours; H460 cells) induces cytotoxic effects at the concentrations from 50 to 100 μM and induces a significant increase in apoptotic and necrotic cells at 20~100 μM[1].
Phoyunnanin E (0~10 μM; 48 hours; H460, H292 and A549 cells) significantly decreases the number of cells invading across the matrix and transwell filter within 24 hours in a dose-dependent manner[1].
Phoyunnanin E attenuates anchorage-independent growth and migration of lung cancer H460 cells. Phoyunnanin E significantly inhibits cell migration across the wound space at the concentrations of 5 and 10 μM, at 24 h and 48 h, compared to the non-treated control. Phoyunnanin E (0~10 μM; 48 hours) exhibits a significant decrease in filopodia numbers at the protrusion edges of the cells in a dose-dependent manner. Phoyunnanin E decreases cancer cell migration in other human lung cancer cells. Phoyunnanin E decreases cancer cell invasion. Phoyunnanin E suppresses epithelial-mesenchymal transition (EMT). Phoyunnanin E down-regulates integrins αv and β3 and the regulatory proteins in cell migration[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Phoyunnanin E 相关抗体:

Western Blot Analysis[1]

Cell Line: H460 cells
Concentration: 1~10 μM
Incubation Time: 48 hours
Result: Decreased cell migration through integrin downregulation.

Cell Proliferation Assay[1]

Cell Line: H460 cells
Concentration: 0~100 μM
Incubation Time: 24 and 48 hours
Result: The proliferation rate of treated cells had significantly decreased in a dose-dependent manner at the concentration of 10 μM at 48 h.

Apoptosis Analysis[1]

Cell Line: H460 cells
Concentration: 0~100 μM
Incubation Time: 24 hours
Result: Induced a significant increase in apoptotic and necrotic cells at 20~100 μM.

Cell Cytotoxicity Assay[1]

Cell Line: H460 cells
Concentration: 0~100 μM
Incubation Time: 24 hours
Result: Induced cytotoxic effects at the concentrations from 50 to 100 μM.

Immunofluorescence[1]

Cell Line: H460, H292 and A549 cells
Concentration: 0~10 μM
Incubation Time: 48 hours
Result: Significantly decreased the number of cells invading across the matrix and transwell filter within 24 hours in a dose-dependent manner.

分子量

482.52

Formula

C30H26O6
CAS 号

886747-60-0
结构分类
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 兰科
  • 石斛
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (529 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Petpiroon N, et al. Phoyunnanin E inhibits migration of non-small cell lung cancer cells via suppression of epithelial-to-mesenchymal transition and integrin αv and integrin β3. BMC Complement Altern Med. 2017;17(1):553. Published 2017 Dec 29.  [Content Brief]

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