Cycloguanil-d6 hydrochloride(Synonyms: 环氯胍盐酸盐 d6 (盐酸盐))

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Cycloguanil-d6 hydrochloride (Synonyms: 环氯胍盐酸盐 d6 (盐酸盐))

Cycloguanil-d6 hydrochloride 是 Cycloguanil hydrochloride 的氘代物。Cycloguanil hydrochloride 是 Proguanil 的活性代谢产物，作用于红细胞和肝细胞中的疟疾裂殖体。

Cycloguanil-d6 hydrochloride(Synonyms: 环氯胍盐酸盐 d6 (盐酸盐))

Cycloguanil-d6 hydrochloride Chemical Structure

CAS No. : 2712364-69-5

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生物活性

Cycloguanil-d6 hydrochloride is the deuterium labeled Cycloguanil hydrochloride. Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

294.21

Formula

C11H9D6Cl2N5
CAS 号

2712364-69-5
中文名称

环氯胍盐酸盐 d6 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105(1):190-200.

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