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Viridicatumtoxin

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Viridicatumtoxin 

Viridicatumtoxin 是从绿色青霉菌中提取的一种新型霉菌毒素，在大鼠体内的 LD50 为 122.4 mg/kg。

Viridicatumtoxin

Viridicatumtoxin Chemical Structure

CAS No. : 39277-41-3

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生物活性

Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a LD50 of 122.4 mg/kg in rats.

体内研究
(In Vivo)

Viridicatumtoxin (60-400 mg/kg; i.p., p.o., s.c; ICR mice, Sprague-Dawley rats and mature Wistar rats (4/5 weeks; 16-20 g/140-150 g)) has no signs of toxicity with p.o. administration. As the dosage increasing (i.p. and p.o.), hepatocytes starts to have pathological changes and deaths occurrs in both mice and rats. Mice and rats which given the viridicatumtoxin by s.c. has no signs of toxicity and none die, but coagulation necrosis is present at the injection site[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice, Sprague-Dawley rats and mature Wistar rats (4/5 weeks; 16-20 g/140-150 g)[2]
Dosage: 60-400 mg/kg
Administration: i.p., p.o., s.c.
Result: Orally with viridicatumtoxin had no signs of toxicity. As the dosage increasing (i.p. and p.o.), hepatocytes started to have pathological changes and deaths occurred in both mice and rats. Mice and rats which given the viridicatumtoxin by s.c. had no signs of toxicity and none died, but coagulation necrosis was present at the injection site.

分子量

565.57

Formula

C30H31NO10
CAS 号

39277-41-3
结构分类
  • Terpenoids
  • Other Terpenoids
初始来源
  • 微生物

Penicillium viridicatum Westling
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (529 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Hutchison RD, et al. Viridicatumtoxin, a new mycotoxin from Penicillium viridicatum Westling. Toxicol Appl Pharmacol. 1973;24(3):507-509.  [Content Brief]

    [2]. Bendele AM, Carlton WW, Nelson GE, Peterson RE, Grove MD. Viridicatumtoxin mycotoxicosis in mice and rats. Toxicol Lett. 1984;22(3):287-291.  [Content Brief]

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