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Ribostamycin (Synonyms: Vistamycin; SF-733)

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Ribostamycin  (Synonyms: Vistamycin; SF-733)

Ribostamycin (Vistamycin) 是一种广谱氨基糖苷类抗生素 (antibiotic)。Ribostamycin 对革兰氏阴性和革兰氏阳性细菌感染有效。Ribostamycin 还抑制 PDI 的伴侣活性。

Ribostamycin (Synonyms: Vistamycin; SF-733)

Ribostamycin Chemical Structure

CAS No. : 25546-65-0

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Ribostamycin 相关产品

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生物活性

Ribostamycin (Vistamycin) is a broad-spectrum aminoglycoside antibiotic. Ribostamycin is effective against Gram-Negative and Gram-Positive bacterial infection. Ribostamycin also inhibits the chaperone activity of PDI[1][2].

IC50 & Target

Aminoglycoside

 

体外研究
(In Vitro)

Ribostamycin 抑制 Borrelia burgdorferi 活性，MIC90 为 32 mg/L[2]。
Ribostamycin (1-100 μM, 0-15 min) 可抑制 PDI 的分子伴侣活性[3]。
Ribostamycin 抑制大肠杆菌 (Escherichia coli) 活性，MIC 为 0.9-7.2 μM[4]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Ribostamycin 相关抗体:

Cell Viability Assay[4]

Cell Line: Escherichia coli strains
Concentration: 0-64 μg/mL
Incubation Time: 14 h
Result: Inhibited Escherichia coli strains with a MIC of 0.9-7.2 μM.

体内研究
(In Vivo)

Ribostamycin (40 mg/kg，肌肉注射，每天，持续 14 天) 对大鼠几乎没有肾毒性 (通过尿液分析评估)[5]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

454.47

Formula

C17H34N4O10
CAS 号

25546-65-0
结构分类
  • Antibiotics
  • Disease Research
  • Antibacterial
  • Antibiotics
  • Other Antibiotics
初始来源
  • 微生物

Streptomyces ribosidificus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (536 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Zheng T, et al. Linear self-assembly formation between gold nanoparticles and aminoglycoside antibiotics. Colloids Surf B Biointerfaces. 2018 Apr 1;164:185-191.  [Content Brief]

    [2]. Hunfeld KP, et al. In vitro activity of mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin and fusidic acid against Borrelia burgdorferi. Int J Antimicrob Agents. 2001 Mar;17(3):203-8.  [Content Brief]

    [3]. Horibe T, et al. Ribostamycin inhibits the chaperone activity of protein disulfide isomerase. Biochem Biophys Res Commun. 2001 Dec 21;289(5):967-72.  [Content Brief]

    [4]. Kong J, et al. Exploration of Antibiotic Activity of Aminoglycosides, in Particular Ribostamycin Alone and in Combination With Ethylenediaminetetraacetic Acid Against Pathogenic Bacteria. Front Microbiol. 2020 Jul 29;11:1718.  [Content Brief]

    [5]. Kitasato I, et al. Comparative nephrotoxicity of ribostamycin and gentamicin in rats evaluated by urinalysis. Drugs Exp Clin Res. 1989;15(6-7):273-89.  [Content Brief]

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