标签归档：nonoate

PAPA NONOate

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
PAPA NONOate  纯度: ≥98.0%

PAPA NONOate 是 NO 供体，一氧化氮释放半衰期为 77 分钟 (22-25°C)。PAPA NONOate 可能是一种潜在的研究糖尿病伤口愈合障碍的物质，通过增加伤口部位的胶原合成率。

PAPA NONOate

PAPA NONOate Chemical Structure

CAS No. : 146672-58-4

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PAPA NONOate 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Anti-diabetic Compound Library
  • Endocrinology Compound Library
  • Alkaloids Library
  • Coagulation and Anti-coagulation Compound Library

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•同靶点蛋白产品:

生物活性

PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3].

体外研究
(In Vitro)

PAPA NONOate (50 μM; 12 h) significantly reduces 70% caspase-3-like activity in caspase-3-overexpressing HUVEC and abolishs the induction of cell death by caspase-3[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

PAPA NONOate 相关抗体:
体内研究
(In Vivo)

PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound[2]
Dosage: 100 μM
Administration: Wounds received 100 μM PAPA NONOate in phosphate buffer
Result: Increased the wound healing rate in test group.

分子量

176.22

Formula

C6H16N4O2
CAS 号

146672-58-4
性状

固体

颜色

White to off-white

结构分类
  • Alkaloids
  • Other Alkaloids
初始来源
  • 内源性代谢物
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro: 

H2O 中的溶解度 : 50 mg/mL (283.74 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.6747 mL 28.3736 mL 56.7472 mL
5 mM 1.1349 mL 5.6747 mL 11.3494 mL
10 mM 0.5675 mL 2.8374 mL 5.6747 mL

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纯度 & 产品资料

纯度: ≥98.0%

Data Sheet (590 KB) SDS (392 KB)

COA (187 KB) IR (267 KB) Others (355 KB) 元素分析报告 (204 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Rössig L, et al. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem. 1999 Mar 12;274(11):6823-6.  [Content Brief]

    [2]. N Dashti, et al. Study of the effect of PAPA NONOate on the rate of diabetic wound healing. African Journal of Biotechnology. 2014.

    [3]. Keefer LK, et al. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. Methods Enzymol. 1996;268:281-93.  [Content Brief]

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