Lipoxin A4-d5(Synonyms: LXA4-d5)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Lipoxin A4-d5 (Synonyms: LXA4-d5)

Lipoxin A4-d5 (LXA4-d5) 是 Lipoxin A4 的氘代物。Lipoxin A4 (LXA4) 是一种内源性脂氧合酶衍生的类二十烷酸调节剂，具有强大的抗炎和促消炎双重特性。Lipoxin A4 抑制与 ERK1/2 和 NF-kB 通路相关的人表皮角质形成细胞 (NHEK) 的增殖以及炎性细胞因子/趋化因子(如IL-6，IL-8等)的产生。Lipoxin A4 抑制血清淀粉样蛋白 A (SAA) 介导的 IL-8 释放，IC50<

Lipoxin A4-d5(Synonyms: LXA4-d5)

Lipoxin A4-d5 Chemical Structure

CAS No. : 1622429-53-1

规格 是否有货
10 μg 询价

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生物活性

Lipoxin A4-d5 (LXA4-d5) is the deuterium labeled Lipoxin A4. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties[1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways[2]. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM[3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

357.50

Formula

C20H27D5O5
CAS 号

1622429-53-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Feng Hu, et al. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes associated with the ERK1/2 and NF-κB pathways. J Dermatol Sci. 2015 Jun;78(3):181-8.

    [3]. Steven Bozinovski, et al. Serum amyloid A opposes lipoxin A₄ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):935-40.

    [4]. Xinxin Liu, et al. Lipoxin A4 and its analog suppress inflammation by modulating HMGB1 translocation and expression in psoriasis.Sci Rep. 2017 Aug 2;7(1):7100.

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