标签归档：methyltetradecanoic

13-Methyltetradecanoic acid (Synonyms: 13-MTD; 13-Methylmyristic acid)

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13-Methyltetradecanoic acid  (Synonyms: 13-MTD; 13-Methylmyristic acid) 纯度: ≥98.0%

13-Methyltetradecanoic acid (13-MTD)，一种具有强效抗癌作用的饱和支链脂肪酸。13-Methyltetradecanoic acid 在多种类型的人类癌细胞中诱导细胞凋亡 (apoptosis)。

13-Methyltetradecanoic acid (Synonyms: 13-MTD; 13-Methylmyristic acid)

13-Methyltetradecanoic acid Chemical Structure

CAS No. : 2485-71-4

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13-Methyltetradecanoic acid 相关产品

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生物活性

13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells[1][2].

体外研究
(In Vitro)

13-Methyltetradecanoic acid (13-MTD; 0-140 μg/mL; 12-24 hours) inhibits cell viability and proliferation in human bladder cancer cells by inducing apoptosis[1].
13-Methyltetradecanoic acid (13-MTD; 70 μg/mL; 2-48 hours) treatments results in significant accumulation of cells with sub-G1 DNA content in a time-dependent manner, with the proportion of sub-G1 phase DNA content ranging from 9.25% to 85.3% over 2-48 hours[1].
13-Methyltetradecanoic acid (13-MTD; 70 μg/mL; 2-24 hours) down-regulates Bcl-2 and up-regulates Bax. This promotes mitochondrial dysfunction, leading to the release of cytochrome c from the mitochondria to the cytoplasm, as well as the proteolytic activation of caspases. 13-Methyltetradecanoic acid down-regulates AKT phosphorylation and activates phosphorylation of p38 and c-Jun N-terminal kinase (JNK)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

13-Methyltetradecanoic acid 相关抗体:

Cell Viability Assay[1]

Cell Line: Bladder cancer cell lines T24, 5637, and UM-UC-3
Concentration: 0 μg/mL, 35 μg/mL, 70 μg/mL, 105 μg/mL, and 140 μg/mL
Incubation Time: 12 hours, 24 hours
Result: Inhibition of cell viability in a dose- and time-dependent manner.

Cell Cycle Analysis[1]

Cell Line: Bladder cancer cell lines T24, 5637, and UM-UC-3
Concentration: 70 μg/mL
Incubation Time: 2 hours, 8 hours, 24 hours, or 48 hours
Result: Resulted in significant accumulation of cells with sub-G1 DNA content in a time-dependent manner.

Western Blot Analysis[1]

Cell Line: T24, 5637, and UM-UC-3 cells
Concentration: 70 μg/mL
Incubation Time: 2 hours, 8 hours, 24 hours
Result: Down-regulated Bcl-2 and up-regulated Bax, and down-regulated AKT phosphorylation and activated phosphorylation of p38 and c-Jun N-terminal kinase (JNK).

体内研究
(In Vivo)

13-Methyltetradecanoic acid (13-MTD; 70 mg/kg/day; oral gavage; daily; for 30 days) significantly suppresses tumor growth in a xenograft model[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/C nude mice injected with Jurkat lymphoma cells[2]
Dosage: 70 mg/kg/day
Administration: Oral gavage; daily; for 30 days
Result: Effectively inhibited the growth in vivo in a xenograft model.

分子量

242.40

Formula

C15H30O2
CAS 号

2485-71-4
性状

固体

颜色

White to off-white

中文名称

13-甲基十四烷酸
结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 植物
  • 豆科
  • 大豆
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

Data Sheet (526 KB) SDS (251 KB)

COA (254 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Tianxin Lin, et al. 13-Methyltetradecanoic acid induces mitochondrial-mediated apoptosis in human bladder cancer cells. Urol Oncol. May-Jun 2012;30(3):339-45.  [Content Brief]

    [2]. Qingqing Cai, et al. 13-methyltetradecanoic acid exhibits anti-tumor activity on T-cell lymphomas in vitro and in vivo by down-regulating p-AKT and activating caspase-3. PLoS One. 2013 Jun 7;8(6):e65308.  [Content Brief]

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