标签归档：kurarinol

Kurarinol (Synonyms: 苦参醇)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Kurarinol  (Synonyms: 苦参醇)

Kurarinol 是一种黄烷酮，在 Sophora flavescens 根中被发现。Kurarinol 是一种竞争性的酪氨酸酶 (tyrosinase) 抑制剂，对蘑菇型酪氨酸酶作用的 IC50 为 0.1 μM 。

Kurarinol (Synonyms: 苦参醇)

Kurarinol Chemical Structure

CAS No. : 855746-98-4

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生物活性

Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase[1].

IC50 & Target

IC50: 0.1 μM (mushroom tyrosinase)[1]
体外研究
(In Vitro)

Kurarinol manifests relatively low cytotoxic activity (EC50>30 μM)[1].
Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism[1].
Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3)[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Kurarinol 相关抗体:
体内研究
(In Vivo)

Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduces serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (120-130g), hypercholesterolemic models[3]
Dosage: 20 mg/kg
Administration: Oral administration, daily, for 3 days
Result: Decreased serum TC, TG, and LDL-C levels.

分子量

456.53

Formula

C26H32O7
CAS 号

855746-98-4
中文名称

苦参醇
结构分类
  • Flavonoids
  • Flavonones
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 豆科
  • 苦参
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (529 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Y B Ryu, et al. Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens. Phytomedicine. 2008 Aug;15(8):612-8.  [Content Brief]

    [2]. Guangwen Shu, et al. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicol Appl Pharmacol. 2014 Dec 1;281(2):157-65.  [Content Brief]

    [3]. Hyun Young Kim, et al. Hypolipidemic effects of Sophora flavescens and its constituents in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Biol Pharm Bull. 2008 Jan;31(1):73-8.  [Content Brief]

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