标签归档：deoxyactein

23-epi-26-Deoxyactein (Synonyms: 27-Deoxyactein)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
23-epi-26-Deoxyactein  (Synonyms: 27-Deoxyactein) 纯度: 99.45%

23-epi-26-Deoxyactein 是天然的、具有口服活性的抗肥胖和抗肿瘤作用的化合物。

23-epi-26-Deoxyactein (Synonyms: 27-Deoxyactein)

23-epi-26-Deoxyactein Chemical Structure

CAS No. : 501938-01-8

规格 价格 是否有货 数量
1 mg ￥3120 In-stock
5 mg ￥7800 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

23-epi-26-Deoxyactein 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Cell Cycle/DNA Damage Compound Library
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Terpenoids Library
  • Anti-Breast Cancer Compound Library
  • Anti-Obesity Compound Library
  • Transcription Factor-Targeted Library
  • Anti-Cancer Natural Product Library
  • Plant-Sourced Natural Product Library
  • Nuclear Receptor Compound Library
  • Heterocyclic Compound Library
  • Metabolic Enzyme Compound Library
  • Bioactive Compound Library Max

•同靶点产品:

•同靶点蛋白产品:

生物活性

23-epi-26-Deoxyactein is a natural and orally active anti-obesity and anti-cancer compound[1][2][3].

体外研究
(In Vitro)

23-epi-26-Deoxyactein (DA :10 μM and 20 μM) inhibits 3T3-L1 adipogenesis through down-regulating the expression of C/ebpα, C/ebpβ, and Pparγ, which are the critical adipogenic transcription factors[1].
23-epi-26-Deoxyactein (DA) promotes mitochondrial biogenesis in pancreatic β-cells preventing methylglyoxal-induced oxidative cell damage and protects osteoblasts against Antimycin A-induced cell damage[2].
23-epi-26-Deoxyactein (DA) inhibits growth of the MCF7 human breast cancer cells and induces cell cycle arrest at G1 (IC50 of 21μM)[3].
23-epi-26-Deoxyactein (0.1-1 μM) protects osteoblasts against Antimycin A-induced cell damage[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

23-epi-26-Deoxyactein 相关抗体:

Cell Differentiation Assay[1]

Cell Line: 3T3-L1 preadipocytes.
Concentration: 0-50 μM.
Incubation Time: 8 days.
Result: 10 μM DA inhibited the adipogenesis of 3T3-L1 preadipocytes mainly at the early stage of differentiation.

体内研究
(In Vivo)

23-epi-26-Deoxyactein (DA: 5 and 10 mg/kg/d) significantly lowers body weight gain, fat mass, and liver weight in HFD-fed mice. 23-epi-26-Deoxyactein (DA) also reduces insulin resistance and serum lipoprotein levels in HFD-fed mice[1].
23-epi-26-Deoxyactein (DA) promotes adipocyte lipolysis in mice through activating the AMPK signaling and SIRT1-FOXO1 pathway[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet induced obesity in C57BL/6 mice[1].
Dosage: 1-10 mg/kg.
Administration: Orally, daily for 12 weeks.
Result: Lowered body weight gain, fat mass, and liver weight.
5 mg/kg/d DA significantly improved HFD-induced glucose intolerance.

分子量

660.83

Formula

C37H56O10
CAS 号

501938-01-8
性状

固体

颜色

White to off-white

结构分类
  • Terpenoids
  • Triterpenes
初始来源
  • 植物
  • 其他科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 99.45%

Data Sheet (531 KB) SDS (251 KB)

COA (269 KB) HNMR (213 KB) LCMS (77 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Jingjing Yuan, et al. Effects of 23-epi-26-deoxyactein on adipogenesis in 3T3-L1 preadipocytes and diet-induced obesity in C57BL/6 mice. Phytomedicine. 2020 Jun 5;76:153264.  [Content Brief]

    [2]. Kwang Sik Suh, et al. Deoxyactein protects pancreatic β-cells against methylglyoxal-induced oxidative cell damage by the upregulation of mitochondrial biogenesis. Int J Mol Med. 2017 Aug;40(2):539-548.  [Content Brief]

    [3]. Einbond, L.S., et al. Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells. Breast Cancer Res. Treat. 83, 221–231. Breast Cancer Res Treat. 2004 Feb;83(3):221-31.  [Content Brief]

    [4]. Eun Mi Choi, et al. Deoxyactein Isolated from Cimicifuga racemosa protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity. J Appl Toxicol. 2013 Jun;33(6):488-94.  [Content Brief]

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务