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Conessine

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Conessine  纯度: ≥98.0%

Conessine 是一种甾体生物碱，是一种有效的选择性组胺 H3 受体 拮抗剂，Ki 分别为 5.4、6.0、5.7 和 25 nM 分别为人、狗、豚鼠和大鼠 H3 受体。具有抗疟活性。

Conessine

Conessine Chemical Structure

CAS No. : 546-06-5

规格 价格 是否有货 数量
5 mg ￥1300 In-stock
10 mg ￥2000 In-stock
50 mg   询价  
100 mg   询价  

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Conessine 相关产品

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生物活性

Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1].

IC50 & Target[1]

Plasmodium

 

H3 Receptor

5.4 nM (Ki)

rat H3 receptor

25 nM (Ki)

Guinea pig H3 Receptor

6.0 nM (Ki)

Dog H3 Receptor

5.7 nM (Ki)

分子量

356.59

Formula

C24H40N2
CAS 号

546-06-5
性状

固体

颜色

White to off-white

结构分类
  • Steroids
初始来源
  • 植物
  • 其他科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

Ethanol 中的溶解度 : 25 mg/mL (70.11 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8043 mL 14.0217 mL 28.0434 mL
5 mM 0.5609 mL 2.8043 mL 5.6087 mL
10 mM 0.2804 mL 1.4022 mL 2.8043 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: ≥98.0%

Data Sheet (600 KB) SDS (251 KB)

COA (266 KB) HNMR (256 KB) MS (183 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Santora VJ, et al. A new family of H3 receptor antagonists based on the natural product Conessine. Bioorg Med Chem Lett. 2008;18(4):1490-1494.  [Content Brief]

    [2]. Kim H, et al. Conessine treatment reduces dexamethasone-induced muscle atrophy by regulating MuRF1 and atrogin-1 expression [published online ahead of print, 2018 Feb 1]. J Microbiol Biotechnol. 2018;10.4014.jmb.1711.11009.  [Content Brief]

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