Skatole-d8(Synonyms: 3-Methylindole-d8; 3-Methyl-1H-indole-d8)

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Skatole-d8 (Synonyms: 3-Methylindole-d8; 3-Methyl-1H-indole-d8)

Skatole-d8 (3-Methylindole-d8) 是 Skatole 的氘代物。Skatole 是肠道菌群产生的物质，通过激活芳基烃受体 (aryl hydrocarbon receptors) 和 p38 调节肠上皮细胞功能。

Skatole-d8(Synonyms: 3-Methylindole-d8; 3-Methyl-1H-indole-d8)

Skatole-d8 Chemical Structure

CAS No. : 697807-03-7

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生物活性

Skatole-d8 (3-Methylindole-d8) is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

139.22

Formula

C9HD8N
CAS 号

697807-03-7
中文名称

粪臭素 d8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Kurata K, et al. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. Biochem Biophys Res Commun. 2019 Mar 19;510(4):649-655.

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