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Diphenhydramine (Synonyms: 苯海拉明) 纯度: 99.08%
Diphenhydramine 是第一代具有抗胆碱能作用的组胺 H1 受体 (histamine H1-receptor) 拮抗剂。Diphenhydramine hydrochloride 能透过血脑屏障。
Diphenhydramine Chemical Structure
CAS No. : 58-73-1
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
10 mM * 1 mL in DMSO | ¥495 | In-stock | |
250 mg | ¥450 | In-stock | |
500 mg | 询价 | ||
1 g | 询价 |
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生物活性 |
Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) [1][2][3]. |
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IC50 & Target |
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体外研究 (In Vitro) |
Diphenhydramine (1-300 μM, 30 s) 可阻断 NMDA 激活的膜电流,这一特性可负责或增加其镇静、镇痛和记忆相关的作用[2]。 Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[2]
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体内研究 (In Vivo) |
Diphenhydramine (0-10 mg/kg, i.v. and p.o.) 与茶苯海明 Dimenhydrinate (HY-B1215) 联合使用时,口服生物利用度更好[3]。 药代动力学分析[3]
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