Polymyxin B1 (Synonyms: 多粘菌素 B1)

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Polymyxin B1  (Synonyms: 多粘菌素 B1) 纯度: ≥96.0%

Polymyxin B1 是一种有效的抗菌脂肽,衍生自多头芽孢杆菌。Polymyxin B1 是 Polymyxin B (HY-A0248) 的主要成分。Polymyxin B1 可以通过与细菌细胞膜的相互作用来诱导细菌细胞裂解。Polymyxin B1 可用于多重耐药性革兰氏阴性菌感染的研究。

Polymyxin B1                                          (Synonyms: 多粘菌素 B1)

Polymyxin B1 Chemical Structure

CAS No. : 4135-11-9

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Polymyxin B1 相关产品

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生物活性

Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment[1][2].

体外研究
(In Vitro)

Polymyxin B1 has antimicrobial activity that againsts Pseudomonas aeruginosa ATCC 27853, Acinetobacter baumannii ATCC BAA 747, Klebsiella pneumoniae ATCC 13883, P. aeruginosa 9019, A. baumannii 1261 and K. pneumoniae VM9 isolates with MIC values of 4 μg/mL, 2 μg/mL, 2 μg/mL, 4 μg/mL, 4 μg/mL and 2 μg/mL, respectively[3].
? Polymyxin B1 strongly inhibits protein synthesis in yeast, and in E. coli and S. aureus[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Polymyxin B1 相关抗体:

体内研究
(In Vivo)

Polymyxin B1 的药代动力学在大鼠模型中进行了静脉内给药 (0.8 mg/kg) 研究。多粘菌素 B1 的浓度-时间曲线下面积大于粘菌素 A 和粘菌素 B。粘菌素 A 粘菌素 B。多粘菌素 B1 的清除率为 2.39 mL/min/kg,血浆蛋白结合率为 82.3%,消除半衰期为79.5 min,AUC0-∞为365 mg?min/L[5]

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1203.48

Formula

C56H98N16O13

CAS 号

4135-11-9

性状

固体

颜色

White to off-white

中文名称

多粘菌素 B1

结构分类
  • Antibiotics
  • Disease Research
  • Antibacterial
  • Antibiotics
  • Other Antibiotics
初始来源
  • 微生物

Bacilus polymyxa

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
In Vitro: 

1 M HCL 中的溶解度 : 10 mg/mL (8.31 mM; 超声加热助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8309 mL 4.1546 mL 8.3092 mL
5 mM 0.1662 mL 0.8309 mL 1.6618 mL
10 mM

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

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体积

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分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

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每只动物的给药体积

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动物数量

由于实验过程有损耗,建议您多配一只动物的量

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工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 96.40%

Data Sheet (610 KB) SDS (252 KB)

COA (201 KB)

产品使用指南 (1538 KB)

参考文献
  • [1]. Kwa AL, et al. Pharmacokinetics of polymyxin B1 in patients with multidrug-resistant Gram-negative bacterial infections. Diagn Microbiol Infect Dis. 2008 Feb;60(2):163-7.  [Content Brief]

    [2]. Berglund NA, et al. Interaction of the antimicrobial peptide polymyxin B1 with both membranes of E. coli: a molecular dynamics study. PLoS Comput Biol. 2015 Apr 17;11(4):e1004180.  [Content Brief]

    [3]. Tam VH, et al. In vitro potency of various polymyxin B components. Antimicrob Agents Chemother. 2011 Sep;55(9):4490-1.  [Content Brief]

    [4]. Alonso MA, et al. Compounds affecting membranes that inhibit protein synthesis in yeast. Antimicrob Agents Chemother. 1979 Dec;16(6):750-6.  [Content Brief]

    [5]. Sivanesan S, et al. Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats. J Nat Prod. 2017 Jan 27;80(1):225-229.  [Content Brief]

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