Derrone

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Derrone 

Derrone 是一种戊烯基异黄酮，是 Aurora 激酶抑制剂，其对 Aurora B 和 Aurora A 的 IC50 值分别为 6 和 22.3 μM。Derrone 显示出抗肿瘤活性。

Derrone

Derrone Chemical Structure

CAS No. : 76166-59-1

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生物活性

Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity[1][2].

IC50 & Target

IC50: 6 μM (Aurora kinase B), 22.3 μM (Aurora kinase A)[1]
体外研究
(In Vitro)

Derrone (30-60 μM, 15 days) significantly inhibits the formation and growth of MCF7 tumor spheroids, with the tumor spheroid growth inhibition (% TGI) of 17.5% and 65.4% for 30 and 60 μM Derrone, respectively[1].
Derrone shows the autophagic features, such as the conversion of LC3-I to LC3-II, the formation of autophagosome and the downregulation of SQSTM1/p62 (p62)[2].
Derrone induces autophagic cell death through intracellular ROS and sustained ERK phosphorylation in A549 cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Derrone 相关抗体:
分子量

336.34

Formula

C20H16O5
CAS 号

76166-59-1
结构分类
  • Flavonoids
  • Isoflavones
  • Phenols
  • Monophenols
初始来源
  • 植物
  • 桑科
  • 橙桑
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (529 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Hoang NT, et al. In Vitro Characterization of Derrone as an Aurora Kinase Inhibitor. Biol Pharm Bull. 2016 Jun 1;39(6):935-45.  [Content Brief]

    [2]. Kang MJ, et al. Derrone induces autophagic cell death through induction of ROS and ERK in A549 cells. PLoS One. 2019 Jun 19;14(6):e0218659.  [Content Brief]

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