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Tephrosin (Synonyms: 灰叶草素; Deguelinol I; Hydroxydeguelin) 纯度: ≥97.0%
Tephrosin 是一种天然类胡萝卜素，具有较强的抗肿瘤活性。Tephrosin 通过诱导受体内化来诱导 EGFR 和 ErbB2 的降解。
Tephrosin Chemical Structure
CAS No. : 76-80-2
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 1 mg | ￥3800 | In-stock | |
| 5 mg | ￥8500 | In-stock | |
| 10 mg | 询价 | ||
| 50 mg | 询价 |
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Tephrosin 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
| 生物活性 |
Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors[1]. |
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| 体外研究 (In Vitro) |
Treatment of HT-29 cells with tephrosin (0-10μM) inhibits both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3, and concomitantly suppresses the activation of the downstream signaling molecules such as Akt and Erk1/2 mitogen-activated protein kinase (MAPK) [1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
410.42 |
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| Formula |
C23H22O7 |
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| CAS 号 |
76-80-2 |
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| 性状 |
固体 |
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| 颜色 |
White to off-white |
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| 中文名称 |
灰叶草素 |
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| 结构分类 |
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| 初始来源 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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| 溶解性数据 |
In Vitro:
DMSO 中的溶解度 : 100 mg/mL (243.65 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO) 配制储备液
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2
动物溶解方案计算器
请输入动物实验的基本信息：
给药剂量 mg/kg 动物的平均体重 g 每只动物的给药体积 μL 动物数量 只 由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
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| 纯度 & 产品资料 |
纯度: ≥97.0%
Data Sheet (603 KB) SDS (459 KB)
COA (174 KB) 产品使用指南 (1538 KB) |
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| 参考文献 |
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