Sodium 3-methyl-2-oxobutanoate-d1 hydrate

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Sodium 3-methyl-2-oxobutanoate-d1 hydrate 

Sodium 3-methyl-2-oxobutanoate-d1 hydrate 是 Sodium 3-methyl-2-oxobutanoate 的氘代物。Sodium 3-methyl-2-oxobutanoate 是大肠杆菌中泛酸的前体。

Sodium 3-methyl-2-oxobutanoate-d1 hydrate

Sodium 3-methyl-2-oxobutanoate-d1 hydrate Chemical Structure

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生物活性

Sodium 3-methyl-2-oxobutanoate-d1 hydrate is the deuterium labeled Sodium 3-methyl-2-oxobutanoate. Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. MAAS WK, et al. alpha-Ketoisovaleric acid, a precursor of pantothenic acid in Escherichia coli. J Bacteriol. 1953 Apr;65(4):388-93.

    [3]. Schauder P, et al. Oral administration of alpha-ketoisovaleric acid or valine in humans: blood kinetics and biochemical effects. J Lab Clin Med. 1984 Apr;103(4):597-605.

    [4]. Coitinho AS, et al. Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats. Brain Res. 2001 Mar 9;894(1):68-73.

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