标签归档：thio

3-(2-Hydroxyethyl) thio withaferin A

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3-(2-Hydroxyethyl) thio withaferin A 

3-(2-Hydroxyethyl) thio withaferin A 是 Withaferin A 的衍生物。Withaferin A 是甾体内酯，可以抑制 NF-kB 的活性，靶作用于波形蛋白 (vimentin)，具有抗炎，抗肿瘤等功效。Withaferin A 是内皮蛋白 C 受体 (EPCR) 脱落的抑制剂。

3-(2-Hydroxyethyl) thio withaferin A

3-(2-Hydroxyethyl) thio withaferin A Chemical Structure

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生物活性

3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding[1][2][3].

分子量

548.73

Formula

C30H44O7S
结构分类
  • Steroids
初始来源
  • 植物
  • 茄科
  • 睡茄
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (526 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Kaileh M, et al. Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. J Biol Chem. 2007 Feb 16;282(7):4253-64. Epub 2006 Dec 6.  [Content Brief]

    [2]. Bargagna-Mohan P, et al. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol. 2007 Jun;14(6):623-34.  [Content Brief]

    [3]. Kakar SS, et al. Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells. Oncotarget. 2017 Aug 10;8(43):74494-74505.  [Content Brief]

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