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Avanafil dibenzenesulfonate (Synonyms: TA1790 dibenzenesulfonate)
Avanafil (TA-1790) dibenzenesulfonate 是一种有效的选择性磷酸二酯酶-5 (PDE-5) 抑制剂,抑制 PDE-5、PDE-6、PDE-4、PDE-10、PDE-8、PDE-7、PDE-2 和 PDE-1 的 IC50 值分别为 5.2 nM、630 nM、5700 nM、6200 nM、12000 nM、27000 nM、51000 nM 和 53000 nM。Avanafil dibenzenesulfonate 激活 NO/cGMP/PKG 信号通路,减少骨密度损失,骨萎缩和氧化应激。Avanafil dibenzenesulfonate 抑制环单磷酸鸟苷 (cGMP) 水解,从而提高 cGMP 水平。Avanafil dibenzenesulfonate 可用于勃起功能障碍和骨质疏松的研究。
Avanafil dibenzenesulfonate Chemical Structure
CAS No. : 330784-48-0
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Avanafil dibenzenesulfonate 的其他形式现货产品:
生物活性 |
Avanafil (TA-1790) dibenzenesulfonate is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil dibenzenesulfonate activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil dibenzenesulfonate inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil dibenzenesulfonate can be used for the research of erectile dysfunction and osteoporosis[1][2][3]. |
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IC50 & Target[3] |
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体外研究 (In Vitro) |
Avanafil (TA-1790) dibenzenesulfonate (0.01-1000 µM) enhances by 45% for electrical field stimulation (1-20 Hz)-induced relaxation responses in corpus cavernosum strips from the diabetic group[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Avanafil (TA-1790) dibenzenesulfonate (10 mg/kg; p.o.; daily, for 30 d; male rat) increases angiogenesis in bone tissue via the activation of NO, cGMP and PKG (NO/cGMP/PKG) signaling-pathway and significantly decreases dexamethasone-induced loss in BMD, bone atrophy, and oxidative stress[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
800.30 |
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Formula |
C35H38ClN7O9S2 |
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CAS 号 |
330784-48-0 |
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结构分类 |
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初始来源 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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纯度 & 产品资料 |
Data Sheet (544 KB) 产品使用指南 (1538 KB)
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参考文献 |
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