标签归档：oxytetracycline

Oxytetracycline dihydrate (Synonyms: 土霉素二水合物)

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Oxytetracycline dihydrate  (Synonyms: 土霉素二水合物)

Oxytetracycline dihydrate 是一种属于四环素类的抗生素。Oxytetracycline dihydrate 强力抑制革兰氏阴性和革兰氏阳性细菌。Oxytetracycline dihydrate 是一种蛋白质合成抑制剂，可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合。Oxytetracycline dihydrate 还具有抗 HSV-1 的活性。

Oxytetracycline dihydrate (Synonyms: 土霉素二水合物)

Oxytetracycline dihydrate Chemical Structure

CAS No. : 6153-64-6

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Oxytetracycline dihydrate 的其他形式现货产品:

Oxytetracycline Oxytetracycline hydrochloride

Oxytetracycline dihydrate 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity[1][2][3].

IC50 & Target[1][3]

Tetracycline

 

HSV-1

 

Bacterial

 

Microbial Metabolite

 

体外研究
(In Vitro)

Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Oxytetracycline dihydrate 相关抗体:
体内研究
(In Vivo)

The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in Morone chrysops x M. saxatilis, the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter[1].
For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

496.46

Formula

C22H28N2O11
CAS 号

6153-64-6
中文名称

土霉素二水合物；地霉素二水合物；氧四环素二水合物
结构分类
  • Antibiotics
  • Disease Research
  • Antibacterial
  • Phenols
  • Monophenols
  • Antibiotics
  • Other Antibiotics
初始来源
  • 微生物
  • 内源性代谢物

Streptomyces rimosus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (541 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Elia AC, et al. Transferability of oxytetracycline (OTC) from feed to carp muscle and evaluation of the antibiotic effects on antioxidant systems in liver and kidney. Fish Physiol Biochem. 2014 Aug;40(4):1055-68.  [Content Brief]

    [2]. Pickens LB, et al. Oxytetracycline biosynthesis. J Biol Chem. 2010 Sep 3;285(36):27509-15.  [Content Brief]

    [3]. Oguz Guvenmez, et al. A New Treatment Method for Herpes Simplex Virus Type 1-related Skin Lesions. Scientific & Academic. 2019; 8(1): 6-8.

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