Norverapamil-d7 hydrochloride(Synonyms: (±)-Norverapamil-d7 hydrochloride; D591-d7 hydrochloride)

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Norverapamil-d7 hydrochloride (Synonyms: (±)-Norverapamil-d7 hydrochloride; D591-d7 hydrochloride)

Norverapamil-d7 ((±)-Norverapamil-d7) hydrochloride 是一种 Norverapamil 氘代物。Norverapamil ((±)-Norverapamil) 是 Verapamil 的 N-去甲基代谢物,也是一种L型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。

Norverapamil-d7 hydrochloride(Synonyms: (±)-Norverapamil-d7 hydrochloride; D591-d7 hydrochloride)

Norverapamil-d7 hydrochloride Chemical Structure

CAS No. : 1216413-74-9

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1 mg ¥1900 询问价格 & 货期
5 mg ¥6700 询问价格 & 货期
10 mg ¥11500 询问价格 & 货期

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生物活性

Norverapamil-d7 ((±)-Norverapamil-d7) hydrochloride is a deuterium labeled Norverapamil. Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

484.08

Formula

C26H30D7ClN2O4

CAS 号

1216413-74-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Adams KN, et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210(3):456-66.

    [2]. Pauli-Magnus C, et al. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82.

    [3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

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