标签归档：mefenamic

Mefenamic acid D4(Synonyms: 甲芬那酸 D4)

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Mefenamic acid D4 (Synonyms: 甲芬那酸 D4)

Mefenamic acid D4 是 Mefenamic acid 的氘代物。Mefenamic acid 是一种非甾体抗炎剂，为竞争性的 hCOX-1 和 hCOX-2 抑制剂，IC50 值分别为 40 nM 和 3 μM。

Mefenamic acid D4(Synonyms: 甲芬那酸 D4)

Mefenamic acid D4 Chemical Structure

CAS No. : 1216745-79-7

规格 价格 是否有货
1 mg ￥2500 询问价格 & 货期
5 mg ￥5500 询问价格 & 货期

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生物活性

Mefenamic acid D4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1][2].

IC50 & Target

hCOX-1

40 nM (IC50)

hCOX-2

3 nM (IC50)

分子量

245.31

Formula

C15H11D4NO2
CAS 号

1216745-79-7
中文名称

甲芬那酸 D4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84.

    [2]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25.

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