Kdo2-Lipid A ammonium

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Kdo2-Lipid A ammonium  纯度: ≥95.0%

Kdo2-Lipid A ammonium 是一种化学定义的脂多糖 (LPS) ,其内毒素活性等同于 LPS。Kdo2-Lipid A ammonium 对 TLR4 具有高度选择性。Kdo2-Lipid A ammonium 刺激 TNFPGE2 的释放。

Kdo2-Lipid A ammonium

Kdo2-Lipid A ammonium Chemical Structure

CAS No. : 1246298-62-3

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生物活性

Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF and PGE2[1].

IC50 & Target

TLR4

 

体外研究
(In Vitro)

Kdo2-Lipid A (1 µM) stimulates the release of both TNF and PGE2 from the adult rat spinal astrocytes cell cultures[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Kdo2-Lipid A ammonium 相关抗体:

RT-PCR[1]

Cell Line: TNF and PGE2
Concentration: 1 µM
Incubation Time:
Result: Amounts of protein (mg) is 6.2 ± 0.6 ng/mL and 1.4 ± 0.3 ng/mL for TNF and PGE2.

体内研究
(In Vivo)

KDO2-Lipid A (i.t.) activates toll-like receptor 4 (TLR4) in rats[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (Male Holzman Sprague-Dawley, 300–400 g) [1]
Dosage: 0.1 to 10 µg
Administration: I.T.; 0.1-10 µg; prior and 15, 30, 60, 90 and 120 min after injection of Kdo2-Lipid A.
Result: Intrathecal injection of 1 µg Kdo2-Lipid A induces allodynia, and the animals appeared to be sick after i.t. injection of Kdo2-Lipid A.

Clinical Trial

分子量

2306.84

Formula

C110H214N6O39P2

CAS 号

1246298-62-3

性状

固体

颜色

White to off-white

结构分类
  • Others
初始来源
  • 微生物

E. coli

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥95.0%

Data Sheet (547 KB) SDS (251 KB)

COA (290 KB)

产品使用指南 (1538 KB)

参考文献
  • [1]. Saito O, et al. Spinal glial TLR4-mediated nociception and production of prostaglandin E(2) and TNF. Br J Pharmacol. 2010;160(7):1754-1764.  [Content Brief]

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