标签归档：liothyronine

Liothyronine hydrochloride (Synonyms: 三碘代甲状腺素盐酸盐; Triiodothyronine hydrochloride; 3,3′,5-Triiodo-L-thyronine hydrochloride; T3 hydrochloride)

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Liothyronine hydrochloride  (Synonyms: 三碘代甲状腺素盐酸盐; Triiodothyronine hydrochloride; 3,3′,5-Triiodo-L-thyronine hydrochloride; T3 hydrochloride)

Liothyronine hydrochloride 是一种有效的甲状腺激素。Liothyronine hydrochloride 是有效的 TRα 和 TRβ 激动剂，对 hTRα 和 hTRβ 的 Ki 值均为 2.33 nM。

Liothyronine hydrochloride (Synonyms: 三碘代甲状腺素盐酸盐; Triiodothyronine hydrochloride; 3,3

Liothyronine hydrochloride Chemical Structure

CAS No. : 6138-47-2

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Liothyronine hydrochloride 的其他形式现货产品:

Liothyronine sodium Liothyronine

Liothyronine hydrochloride 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

Liothyronine hydrochloride is an active form of thyroid hormone. Liothyronine hydrochloride is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].

IC50 & Target

TRβ1[1][2]
体外研究
(In Vitro)

Liothyronine (T3, 100 nM) hydrochloride stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. Liothyronine hydrochloride binds to human β1 thyroid hormone receptor (hTRβ1), and changes its conformation. Liothyronine hydrochloride promotes growth, induces differentiation and regualtes metabolic effects[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Liothyronine hydrochloride 相关抗体:
Clinical Trial

分子量

687.43

Formula

C15H13ClI3NO4
CAS 号

6138-47-2
中文名称

三碘代甲状腺素盐酸盐
结构分类
  • Phenols
  • Monophenols
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (528 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Lin KH, et al. Stimulation of proliferation by 3,3′,5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.  [Content Brief]

    [2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3′,5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.  [Content Brief]

    [3]. Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34.  [Content Brief]

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