Bupropion-d9 hydrochloride(Synonyms: Amfebutamone-d9 hydrochloride)

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Bupropion-d9 hydrochloride (Synonyms: Amfebutamone-d9 hydrochloride)

Bupropion-d9 (Amfebutamone-d9) hydrochloride 是 Bupropion hydrochloride 的氘代物。Bupropion (Amfebutamone) hydrochloride 是一种口服有效,选择性的 5-羟色胺再摄取抑制剂 (SSRI)。Bupropion hydrochloride 阻断多巴胺 (DA) 摄取或 Methamphetamine 诱导的 DA 释放,IC50 分别为 1.76 μM 和 14.2 μM。Bupro

Bupropion-d9 hydrochloride(Synonyms: Amfebutamone-d9 hydrochloride)

Bupropion-d9 hydrochloride Chemical Structure

CAS No. : 1189725-26-5

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生物活性

Bupropion-d9 (Amfebutamone-d9) hydrochloride is the deuterium labeled Bupropion hydrochloride. Bupropion (Amfebutamone) hydrochloride is an orally active, selective serotonin reuptake inhibitor (SSRI).Bupropion block dopamine (DA) uptake or Methamphetamine-induced DA release with IC50s of 1.76 μM and 14.2 μM, respectively. Bupropion hydrochloride is an atypical antidepressant of the aminoketone group. Bupropion hydrochloride can be used for the research of smoking cessation aid[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

285.26

Formula

C13H10D9Cl2NO

CAS 号

1189725-26-5

中文名称

盐酸安非他酮 d9 (盐酸盐)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. C Lindsay DeVane. Antidepressant-drug interactions are potentially but rarely clinically significant. Neuropsychopharmacology. 2006 Aug;31(8):1594-604; discussion 1614-5.

    [3]. Linda D Simmler, et al. Bupropion, methylphenidate, and 3,4-methylenedioxypyrovalerone antagonize methamphetamine-induced efflux of dopamine according to their potencies as dopamine uptake inhibitors: implications for the treatment of methamphetamine dependence. BMC Res Notes. 2013 Jun 5;6:220.

    [4]. Eun-Hee Jang, et al. Bupropion, an atypical antidepressant, induces endoplasmic reticulum stress and caspase-dependent cytotoxicity in SH-SY5Y cells. Toxicology. 2011 Jul 11;285(1-2):1-7.

    [5]. Piotr Tutka, et al. Convulsant and anticonvulsant effects of bupropion in mice. Eur J Pharmacol. 2004 Sep 19;499(1-2):117-20.

    [6]. Moreira, R., The efficacy and tolerability of bupropion in the treatment of major depressive disorder. Clin Drug Investig, 2011. 31 Suppl 1: p. 5-17.

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