标签归档：kushenol

Kushenol K (Synonyms: 苦参醇K)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Kushenol K  (Synonyms: 苦参醇K)

Kushenol K，一种从 Sophora flavescens 中提取的黄酮类抗氧化剂。Kushenol K 是 CYP3A4 的抑制剂，Ki 值为 1.35 μM。Kushenol K 对 HSV-2 具有较弱的抗病毒活性 (EC50 为 147 μM)。Kushenol K 还抑制 SGLT1 和 SGLT2 的活性。

Kushenol K (Synonyms: 苦参醇K)

Kushenol K Chemical Structure

CAS No. : 101236-49-1

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Kushenol K 相关产品

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生物活性

Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3].

IC50 & Target[1][2][3]

CYP3A4

1.35 μM (Ki)

CYP3

 

SGLT1

 

SGLT2

 

HSV-2

147 μM (EC50)

体外研究
(In Vitro)

When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC50 values of 1.62 µM[1].
At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Kushenol K 相关抗体:
分子量

472.53

Formula

C26H32O8
CAS 号

101236-49-1
中文名称

苦参醇K；苦参醇 K
结构分类
  • Flavonoids
  • Flavanonols
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 豆科
  • 苦参
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (530 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Yannan Li, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.  [Content Brief]

    [2]. E R Woo, et al. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod. 1998 Dec;61(12):1552-4.  [Content Brief]

    [3]. Seizo Sato, et al. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9.  [Content Brief]

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