Centanafadine-d7 hydrochloride(Synonyms: EB-1020-d7 hydrochloride)

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Centanafadine-d7 hydrochloride (Synonyms: EB-1020-d7 hydrochloride)

Centanafadine-d7 (EB-1020-d7) hydrochloride 是 Centanafadine hydrochloride 的氘代物。Centanafadine hydrochloride 是去甲肾上腺素 (NE)/多巴胺 (DA) 转运的双抑制剂,还能抑制5-羟色胺 (serotonin) 转运体,其对人 NE,DA 和5-羟色胺转运体的IC50 值分别为6 nM,38 nM 和 83 nM。

Centanafadine-d7 hydrochloride(Synonyms: EB-1020-d7 hydrochloride)

Centanafadine-d7 hydrochloride Chemical Structure

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生物活性

Centanafadine-d7 (EB-1020-d7) hydrochloride is the deuterium labeled Centanafadine hydrochloride. Centanafadine hydrochloride is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

252.79

Formula

C15H9D7ClN

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Bymaster FP, et al. Pharmacological characterization of the norepinephrine and dopamine reuptake inhibitor EB-1020: implications for treatment of attention-deficit hyperactivity disorder. Synapse. 2012 Jun;66(6):522-32.

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