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ATP dipotassium (Synonyms: 腺苷三磷酸二钾盐; Adenosine 5′-triphosphate dipotassium)

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ATP dipotassium  (Synonyms: 腺苷三磷酸二钾盐; Adenosine 5′-triphosphate dipotassium)

ATP dipotassium (Adenosine 5′-triphosphate dipotassium) 是体内能量储存和代谢的重要物质，为代谢提供能量，同时在细胞中作为辅酶发挥作用。ATP dipotassium 是免疫和炎症中重要的内源性信号分子。

ATP dipotassium (Synonyms: 腺苷三磷酸二钾盐; Adenosine 5

ATP dipotassium Chemical Structure

CAS No. : 42373-41-1

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ATP dipotassium 的其他形式现货产品:

ATP ATP disodium trihydrate ATP-15N5 dilithium

ATP dipotassium 相关产品

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生物活性

ATP dipotassium (Adenosine 5′-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo. ATP dipotassium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation[1][2].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

ATP dipotassium (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP dipotassium (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4].
ATP dipotassium promotes neutrophil chemotaxis in vitro[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

ATP dipotassium 相关抗体:
体内研究
(In Vivo)

ATP dipotassium (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
ATP dipotassium induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four-week-old Kunming mice (18-22 g)[4]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection, before bacterial (E. coli) challenge
Result: Protected mice from bacterial infection.

分子量

585.38

Formula

C10H16K2N5O13P3
CAS 号

42373-41-1
中文名称

腺苷三磷酸二钾盐
结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 植物
  • 其他科
  • 动物
  • 内源性代谢物

widespread
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (537 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Bonora M, et al. ATP synthesis and storage. Purinergic Signal. 2012 Sep;8(3):343-57.  [Content Brief]

    [2]. M J L Bours, et al. Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404.  [Content Brief]

    [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.  [Content Brief]

    [4]. Yang Xiang, et al. Adenosine-5′-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.  [Content Brief]

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