Prulifloxacin-d8(Synonyms: 普卢利沙星 d8)

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Prulifloxacin-d8 (Synonyms: 普卢利沙星 d8)

Prulifloxacin-d8 (NM441-d8) 是 Prulifloxacin 的氘代物。Prulifloxacin (NM441) 是一种口服有效的氟喹诺酮抗生素 (antibiotic)，对革兰氏阳性和阴性细菌具有广泛的活性。Prulifloxacin 是噻唑喹啉羧酸衍生物 Ulifloxacin (NM394) 的前药。Prulifloxacin 有潜力用于下尿路感染和慢性支气管炎。

Prulifloxacin-d8(Synonyms: 普卢利沙星 d8)

Prulifloxacin-d8 Chemical Structure

CAS No. : 1246819-37-3

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生物活性

Prulifloxacin-d8 (NM441-d8) is the deuterium labeled Prulifloxacin. Prulifloxacin (NM441) is an orally active fluoroquinolone antibiotic with a broad spectrum of activity against Gram-positive and -negative bacteria. Prulifloxacin is a prodrug of a thiazeto-quinoline carboxylic acid derivative Ulifloxacin (NM394). Prulifloxacin has the potential for lower urinary tract infections and exacerbations of chronic bronchitis[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

469.51

Formula

C21H12D8FN3O6S
CAS 号

1246819-37-3
中文名称

普卢利沙星 d8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. 4/

    [2]. M Ozaki, et al. In vivo evaluation of NM441, a new thiazeto-quinoline derivative. Antimicrob Agents Chemother. 1991 Dec;35(12):2496-9.

    [3]. Guillem Prats, et al. Prulifloxacin: a new antibacterial fluoroquinolone. Expert Rev Anti Infect Ther. 2006 Feb;4(1):27-41.

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