Acivicin (Synonyms: 阿西维辛; AT-125; U-42126)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
Acivicin  (Synonyms: 阿西维辛; AT-125; U-42126)

Acivicin (AT-125) 是一种由猪链霉菌产生的天然产物,是 γ-谷氨酰转肽酶 (GGT) 抑制剂。Acivicin 可以透过血脑屏障,并具有抗癌,抗寄生虫的特性。

Acivicin                                          (Synonyms: 阿西维辛; AT-125;  U-42126)

Acivicin Chemical Structure

CAS No. : 42228-92-2

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Acivicin 的其他形式现货产品:

Acivicin hydrochloride

Acivicin 相关产品

同靶点产品:

同靶点蛋白产品:

生物活性

Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].

IC50 & Target

γ-glutamyl transpeptidase[1]

体外研究
(In Vitro)

Acivicin (AT-125; 0.1-50 μM; 5 days) has an IC50 of 0.7 μM in human HepG2 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Acivicin 相关抗体:

体内研究
(In Vivo)

Acivicin (AT-125; 5 mg/kg; IP; twice weekly) reduces urinary γ-GT by 70-78%[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene[3]
Dosage: 5 mg/kg
Administration: IP; twice weekly (monday and wednesday)
Result: Reduced urinary γ-GT by 70-78%.

分子量

178.57

Formula

C5H7ClN2O3

CAS 号

42228-92-2

性状

固体

颜色

White to light yellow

中文名称

阿西维辛;异恶唑醋酸

结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 微生物

Streptomyces sviceus

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 6.67 mg/mL (37.35 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.6000 mL 28.0002 mL 56.0004 mL
5 mM 1.1200 mL 5.6000 mL 11.2001 mL
10 mM 0.5600 mL 2.8000 mL 5.6000 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

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浓度

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体积

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分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

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动物的平均体重

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每只动物的给药体积

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由于实验过程有损耗,建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

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纯度 & 产品资料

纯度: 98.26% ee.: 99.96%

Data Sheet (601 KB) SDS (252 KB)

COA (265 KB) HNMR (258 KB) RP-HPLC (255 KB) NP-HPLC (118 KB)

产品使用指南 (1538 KB)

参考文献
  • [1]. Kreuzer J, et al. Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition. Chem Sci. 2014 Dec 1;6(1):237-245. Epub 2014 Sep 26.  [Content Brief]

    [2]. Chikhale EG, et al. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier. Biochem Pharmacol. 1995 Mar 30;49(7):941-5.  [Content Brief]

    [3]. Delphine Waniusiow, et al. Toluene-induced hearing loss in acivicin-treated rats. Neurotoxicol Teratol. May-Jun 2008;30(3):154-60.  [Content Brief]

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