上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
Fenspiride hydrochloride (Synonyms: 芬司匹利盐酸盐;盐酸芬司必利;盐酸芬司匹利;芬司必利盐酸盐) 纯度: 99.97%
Fenspiride 是一种口服活性的非甾体抗炎剂,是 H1-组胺受体 (H1-histamine receptors) 的拮抗剂。Fenspiride 抑制磷酸二酯酶 3 (PDE3)、磷酸二酯酶 4 (PDE4)和磷酸二酯酶 5 (PDE5) 的活性,-log IC50 值分别为 3.44、4.16 和大约 3.8。Fenspiride 可用于呼吸系统疾病的研究。
Fenspiride hydrochloride Chemical Structure
CAS No. : 5053-08-7
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Free Sample (0.1 – 0.2 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥825 | In-stock | |
100 mg | ¥750 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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生物活性 |
Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases[1][2][3]. |
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IC50 & Target[2] |
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体外研究 (In Vitro) |
Fenspiride (around 100 μM) inhibits histamine-induced contraction of isolated guinea pig trachea[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Fenspiride (60 mg/kg; p.o. for 3 days) reduces the lipopolysaccharide-induced early rise of tumor necrosis factor concentrations in serum and in the bronchoalveolar lavage fluid (BALF) of the model of endotoxemia[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
296.79 |
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Formula |
C15H21ClN2O2 |
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CAS 号 |
5053-08-7 |
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性状 |
固体 |
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颜色 |
White to off-white |
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中文名称 |
芬司匹利盐酸盐;盐酸芬司必利;盐酸芬司匹利;芬司必利盐酸盐 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
H2O 中的溶解度 : 50 mg/mL (168.47 mM; 超声助溶) DMSO 中的溶解度 : 33.33 mg/mL (112.30 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO) 配制储备液
查看完整储备液配制表
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2
In Vivo:
请根据您的 实验动物和给药方式 选择适当的溶解方案。 以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
以下溶解方案,请直接配置工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。
动物溶解方案计算器
请输入动物实验的基本信息:
给药剂量 mg/kg 动物的平均体重 g 每只动物的给药体积 μL 动物数量 只 由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
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纯度 & 产品资料 |
纯度: 99.97%
Data Sheet (625 KB) SDS (393 KB)
COA (263 KB) RP-HPLC (77 KB) 产品使用指南 (1538 KB) |
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参考文献 |
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