Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits ATP citrate lyase with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects^[1][2][3][4].

Lithium citrate tetrahydrate shows an HIF inhibitory effect compared with the control group in ARPE19 cells and 661W cells. Lithium citrate tetrahydrate can downregulate Hif1a and the downstream genes in ARPE19 cells and 661W cells. Lithium citrate tetrahydrate suppresses HIF-1α protein expression increased by CoCl₂ administration in ARPE19 cells and 661W cells^[2].
In chicken hepatocytes, Lithium citrate tetrahydrate decreases the accumulation of lipid droplets and accelerated energy metabolism. Lithium citrate tetrahydrate protects the cells from ER stress by increasing the antioxidant status and mitochondrial functions^[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Lithium citrate (100-200 mg/kg) tetrahydrate treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There is significantly less calcium oxalate crystal deposition in mice (male C57BL/6J mice) treated with Lithium citrate tetrahydrate. Lithium citrate tetrahydrate attenuates the oxidative stress induced by calcium oxalate crystallization. Lithium citrate tetrahydrate has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, and IL-6. In addition, Lithium citrate tetrahydrate alleviates tubular injury and apoptosis caused by calcium oxalate crystals^[1].
The administration of Lithium citrate tetrahydrate can suppress body weight gain and fat accumulation in animals^[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

281.98

C₆H₁₃Li₃O₁₁

6080-58-6

固体

White to off-white

柠檬酸三锂盐四水合物

• Ketones, Aldehydes, Acids

• 微生物

Aspergillus niger

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O 中的溶解度 : ≥ 100 mg/mL (354.64 mM)

* “≥” means soluble, but saturation unknown.

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• 方案 一

  请依序添加每种溶剂： PBS

  Solubility: 50 mg/mL (177.32 mM); 澄清溶液; 超声助溶

• [1]. Liu X, et al. Hydroxycitric acid inhibits renal calcium oxalate deposition by reducing oxidative stress and inflammation. Curr Mol Med. 2020 Jan 3.  [Content Brief]

  [2]. Ibuki M, et al. Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration. Int J Mol Sci. 2019 Oct 11;20(20). pii: E5049.  [Content Brief]

  [3]. Han S, et al. Hydroxycitric Acid Tripotassium Inhibits Calcium Oxalate Crystal Formation in the Drosophila Melanogaster Model of Hyperoxaluria. Med Sci Monit. 2019 May 17;25:3662-3667.  [Content Brief]

  [4]. Heymsfield SB, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998 Nov 11;280(18):1596-600.  [Content Brief]