Pregnenolone monosulfate-d4 sodium(Synonyms: 3β-Hydroxy-5-pregnen-20-one monosulfate-d4 sodium)

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Pregnenolone monosulfate-d4 sodium (Synonyms: 3β-Hydroxy-5-pregnen-20-one monosulfate-d4 sodium)

Pregnenolone monosulfate-d4 (sodium) 是 Pregnenolone monosulfate 氘代物。Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) 是一种功能强大的神经甾体，是包括甾体酮在内的各种甾体激素的主要前体。Pregnenolone monosulfate sodium 是大麻素 CB1 受体的信号传导特异性抑制剂，抑制由 CB1

Pregnenolone monosulfate-d4 sodium(Synonyms: 3β-Hydroxy-5-pregnen-20-one monosulfate-d4 sodium)

Pregnenolone monosulfate-d4 sodium Chemical Structure

CAS No. : 1485492-21-4

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生物活性

Pregnenolone monosulfate-d4 (sodium) is the deuterium labeled Pregnenolone monosulfate. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

422.55

Formula

C21H27D4NaO5S
CAS 号

1485492-21-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8.

    [3]. Ducharme N, et al. Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol. 2010 Sep 1;641(2-3):128-34.

    [4]. Alan Shiels. TRPM3_miR-204: a complex locus for eye development and disease. Hum Genomics. 2020 Feb 18;14(1):7.

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