Taurochenodeoxycholic acid-d5 sodium(Synonyms: 12-Deoxycholyltaurine-d5 sodium)

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Taurochenodeoxycholic acid-d5 sodium (Synonyms: 12-Deoxycholyltaurine-d5 sodium)

Taurochenodeoxycholic acid-d5 (12-Deoxycholyltaurine-d5) sodium 是 Taurochenodeoxycholic acid sodium 的氘代物。Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) 是动物胆汁酸的主要生物活性物质之一。Taurochenodeoxycholic acid 可诱导细胞凋亡 (apoptosis)，并具有

Taurochenodeoxycholic acid-d5 sodium(Synonyms: 12-Deoxycholyltaurine-d5 sodium)

Taurochenodeoxycholic acid-d5 sodium Chemical Structure

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生物活性

Taurochenodeoxycholic acid-d5 (12-Deoxycholyltaurine-d5) sodium is the deuterium labeled Taurochenodeoxycholic acid sodium. Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) is one of the main bioactive substances of animals’ bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

526.72

Formula

C26H39D5NNaO6S
中文名称

牛磺鹅去氧胆酸钠盐 d5 (钠盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Wang X, et al. Taurochenodeoxycholic acid induces NR8383 cells apoptosis via PKC/JNK-dependent pathway. Eur J Pharmacol. 2016 Sep 5;786:109-15.

    [3]. Zhou C, et al. The effects of taurochenodeoxycholic acid in preventing pulmonary fibrosis in mice. Pak J Pharm Sci. 2013 Jul;26(4):761-5.

    [4]. Uchida A, et al. Taurochenodeoxycholic acid ameliorates and ursodeoxycholic acid exacerbates small intestinal inflammation. Am J Physiol. 1997 May;272(5 Pt 1):G1249-57.

    [5]. Liu M, et al. Effects of taurochenodeoxycholic acid on adjuvant arthritis in rats. Int Immunopharmacol. 2011 Dec;11(12):2150-8.

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