Didesethyl chloroquine-d4(Synonyms: Bisdesethylchloroquine-d4)

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Didesethyl chloroquine-d4 (Synonyms: Bisdesethylchloroquine-d4)

Didesethyl chloroquine-d4 (Bisdesethylchloroquine-d4) 是 Didesethyl chloroquine 的氘代物。Didesethyl chloroquine (Bisdesethylchloroquine) 是抗疟药 Chloroquine 的主要代谢物。Didesethyl chloroquine 是强效的心肌抑制剂。

Didesethyl chloroquine-d4(Synonyms: Bisdesethylchloroquine-d4)

Didesethyl chloroquine-d4 Chemical Structure

CAS No. : 1215797-41-3

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生物活性

Didesethyl chloroquine-d4 (Bisdesethylchloroquine-d4) is the deuterium labeled Didesethyl chloroquine. Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial drug Chloroquine. Didesethyl chloroquine is a potent myocardial depressant[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

267.79

Formula

C14H14D4ClN3
CAS 号

1215797-41-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Biot C, et al. Synthesis and antimalarial activity in vitro of potential metabolites of ferrochloroquine and related compounds. Bioorg Med Chem. 1999 Dec;7(12):2843-7.

    [3]. Essien EE, et al. Effects of chloroquine and didesethylchloroquine on rabbit myocardium and mitochondria. J Pharm Pharmacol. 1986 Jul;38(7):543-6.

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