Zomepirac-d4 sodium salt(Synonyms: 佐美酸钠 d4 (钠盐))

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Zomepirac-d4 sodium salt (Synonyms: 佐美酸钠 d4 (钠盐))

Zomepirac-d4 sodium salt 是 Zomepirac sodium salt 的氘代物。Zomepirac sodium salt (McN-2783-21-98) 是一种有效的前列腺素合成酶 (prostaglandin biosynthesis) 抑制剂。Zomepirac sodium salt 是一种非甾体抗炎药 (NSAID)。Zomepirac sodium salt 可引起免疫介导的肝损伤。

Zomepirac-d4 sodium salt(Synonyms: 佐美酸钠 d4 (钠盐))

Zomepirac-d4 sodium salt Chemical Structure

CAS No. : 85577-28-2

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生物活性

Zomepirac-d4 sodium salt is the deuterium labeled Zomepirac sodium salt. Zomepirac sodium salt (McN-2783-21-98) is a potent prostaglandin biosynthesis inhibitor. Zomepirac sodium salt is a non-steroidal anti-inflammatory drug (NSAID). Zomepirac sodium salt can cause immune-mediated liver injury[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

317.74

Formula

C15H10D4ClNNaO3
CAS 号

85577-28-2
中文名称

佐美酸钠 d4 (钠盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Min Wang, et al. Hepatic covalent adduct formation with zomepirac in the CD26-deficient mouse. J Gastroenterol Hepatol. 2002 Jan;17(1):66-71.

    [3]. T P Pruss, et al. Evaluation of the analgesic properties of zomepirac. J Clin Pharmacol. 1980 Apr;20(4):216-22.

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