Norverapamil-d7(Synonyms: (±)-Norverapamil-d7; D591-d7)

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Norverapamil-d7 (Synonyms: (±)-Norverapamil-d7; D591-d7)

Norverapamil-d7 ((±)-Norverapamil-d7) 是 Norverapamil ((±)-Norverapamil) 的氘代物。Norverapamil 是 Verapamil 的 N-去甲基代谢物，是一种钙通道 (L-type calcium channel) 阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。

Norverapamil-d7(Synonyms: (±)-Norverapamil-d7; D591-d7)

Norverapamil-d7 Chemical Structure

CAS No. : 263175-44-6

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生物活性

Norverapamil-d7 ((±)-Norverapamil-d7) is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

分子量

447.62

Formula

C26H29D7N2O4
CAS 号

263175-44-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Adams KN, et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210(3):456-66.

    [2]. Pauli-Magnus C, et al. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82.

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