Girinimbine (Synonyms: Girinimbin)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
Girinimbine  (Synonyms: Girinimbin)

Girinimbine (Girinimbin) 是一种咔唑类生物碱,具有多种生物学作用。Girinimbine 可诱导细胞凋亡 (apoptosis),具有抗锥虫、抗血小板活性、抗菌活性、抗炎、抗氧化和抗肿瘤活性。

Girinimbine                                          (Synonyms: Girinimbin)

Girinimbine Chemical Structure

CAS No. : 23095-44-5

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生物活性

Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities[1][2][3].

体外研究
(In Vitro)

Girinimbine (1-400 µM; 24-72 h) decreases the viability of HepG2 cells in 24, 48 and 72 h with IC50 values of 61 µM, 56 µM, and 40 µM respectively. Girinimbine (10-100 µM; 24-48 h) increase of LDH leakage in both concentration- and time-dependent manner in HepG2 cells[1].
Girinimbine (56 µM; 24-48 h) treatment results in DNA fragmentation and elevates levels of caspase-3 in HepG2 cells[1]. HepG2 cells[1].
Girinimbine (56 µM; 12-48 h) treatment also displays a time-dependent accumulation of the Sub-G0/G1 peak (hypodiploid) and caused G0/G1-phase arrest[1].
Girinimbine shows a potent antitrypanosomal activitywith an IC50 value of 10.16 µg/mL[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Girinimbine 相关抗体:

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 1 µM, 10 µM, 50 µM, 100 µM, 200 µM
Incubation Time: 24 h, 48 h and 72 h
Result: Inhibited the proliferation of HepG2 cells in vitro in a dose- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: HepG2 cells
Concentration: 56 µM
Incubation Time: 24 h, 48 h
Result: Showed typical morphological features of apoptosis.

Cell Cycle Analysis[1]

Cell Line: HepG2 cells
Concentration: 56 µM
Incubation Time: 12 h, 24 h, 48 h
Result: Induced G0/G1-phase arrest in HepG2 cells.

体内研究
(In Vivo)

Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, and reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid[2].
In vivo in zebrafish embryos, Girinimbine (20 μg/mL; 24 hours) shows significant distribution of apoptotic cells in embryos[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (25-35 g) treated with carrageenan[2]
Dosage: 10 mg/kg, 30 mg/kg, and 100 mg/kg
Administration: Orally gavage; once
Result: Helped limit total leukocyte migration, and reduced pro-inflammatory cytokine levels in the peritoneal fluid.

分子量

263.33

Formula

C18H17NO

CAS 号

23095-44-5

性状

固体

颜色

Off-white to light yellow

中文名称

吉九里香碱

结构分类
  • Alkaloids
  • Indole Alkaloids
初始来源
  • 植物
  • 芸香科
  • 调料九里香
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
Data Sheet (537 KB) 产品使用指南 (1538 KB)

参考文献
  • [1]. Suvitha Syam, et al. The growth suppressing effects of girinimbine on HepG2 involve induction of apoptosis and cell cycle arrest. Molecules. 2011 Aug 23;16(8):7155-70.  [Content Brief]

    [2]. Venoos Iman, et al. Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii. Drug Des Devel Ther. 2016 Dec 28;11:103-121.  [Content Brief]

    [3]. H O Dyary, et al. Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb. Trop Biomed. 2019 Mar 1;36(1):94-102.  [Content Brief]

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