Shishijimicin B

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Shishijimicin B 

Shishijimicin B 是烯二炔类活性化合物。Shishijimicin B 表现出极强的细胞毒性，IC50 值为 2.0 – 3.3 nM。Shishijimicin B 具有抗肿瘤活性，可用于癌症的研究。

Shishijimicin B

Shishijimicin B Chemical Structure

CAS No. : 503860-51-3

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Shishijimicin B 相关产品

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生物活性

Shishijimicin B is an active compound of the enediyne class. Shishijimicin B shows extremely potent cytotoxicity with IC50 values of 2.0-3.3 nM. Shishijimicin B has antitumor activity and can be used for the research of cancer[1]. Shishijimicin B is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

IC50: 3.1 nM (3Y1 cells); 3.3 nM (Hela cells); 2.0 nM (P388 cells)[1]
体外研究
(In Vitro)

Shishijimicin B (compound 2) has high cytotoxicity for 3Y1, Hela and P388 cells with IC50 values of 3.1 nM, 3.3 nM and 2.0 nM, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Shishijimicin B 相关抗体:
分子量

935.09

Formula

C45H50N4O12S3
CAS 号

503860-51-3
结构分类
  • Alkaloids
  • Pyridine Alkaloids
  • Alkaloids
  • Indole Alkaloids
  • Others
初始来源
  • 动物

Didemnum proliferum
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (536 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Naoya Oku, et al. Shishijimicins A-C, novel enediyne antitumor antibiotics from the ascidian Didemnum proliferum(1). J Am Chem Soc. 2003 Feb 26;125(8):2044-5.  [Content Brief]

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