Guanosine 5′-diphosphate sodium (Synonyms: GDP sodium)

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Guanosine 5′-diphosphate sodium (Synonyms: GDP sodium)

Guanosine 5′-diphosphate (GDP) sodium 是一种核苷二磷酸，可激活 5′-三磷酸腺苷敏感的 K⁺ 通道。Guanosine 5′-diphosphate sodium 是一种潜在的铁动员剂，可阻断铁调素-铁转运蛋白 (hepcidin-ferroportin ) 相互作用并调节 IL-6/stat-3 通路。Guanosine 5′-diphosphate sodium 可用于炎症研究，如炎症性贫血 (AI)。

Guanosine 5′-diphosphate sodium Chemical Structure

CAS No. : 43139-22-6

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Guanosine 5′-diphosphate sodium 的其他形式现货产品:

Guanosine 5′-diphosphate disodium salt

Guanosine 5′-diphosphate sodium 相关产品

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生物活性

Guanosine 5′-diphosphate (GDP) sodium is a nucleoside diphosphate that activates adenosine 5′-triphosphate-sensitive K⁺ channel. Guanosine 5′-diphosphate sodium is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5′-diphosphate sodium can be used in the research of inflammation, such as anemia of inflammation (AI)^[1]^[2].

IC₅₀ & Target

K+ channel^[1], endogenous metabolite^[2].

Clinical Trial

分子量

465.18

Formula

C₁₀H₁₄N₅NaO₁₁P₂

CAS 号

43139-22-6

中文名称

鸟苷-5’-二磷酸钠盐

结构分类

Others

初始来源

内源性代谢物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

Data Sheet (536 KB) 产品使用指南 (1538 KB)

参考文献

[1]. S Kajioka, et al. Guanosine diphosphate activates an adenosine 5′-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418. [Content Brief]

[2]. Angmo S, et al. Identification of Guanosine 5′-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097. [Content Brief]

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